Chemokine decoy receptors: New players in reproductive immunology

Elena Monica Borroni, Raffaella Bonecchi, Chiara Buracchi, Benedetta Savino, Alberto Mantovani, Massimo Locati

Research output: Contribution to journalArticlepeer-review


Chemokines are multifunctional molecules with roles in leukocyte trafficking and developmental processes. Both fetal and maternal components of the placenta produce chemokines, which control leukocyte trafficking observed in the placenta. Thus, chemokines play roles in the balance between protection of the developing embryo/fetus and tolerance of its hemiallogeneic tissues. Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as "silent" receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction. Here we review in vitro and in vivo evidence indicating that chemokine "silent" receptors regulate innate and adaptive immunity behaving as decoy receptors that support internalization and degradation of chemotactic factors, and discuss available information on their potential role in reproductive immunology.

Original languageEnglish
Pages (from-to)483-497
Number of pages15
JournalImmunological Investigations
Issue number5-6
Publication statusPublished - Jul 2008


  • Chemokine
  • Decoy receptor
  • Inflammation
  • Placenta

ASJC Scopus subject areas

  • Immunology


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