TY - JOUR
T1 - Chemokine decoy receptors
T2 - New players in reproductive immunology
AU - Borroni, Elena Monica
AU - Bonecchi, Raffaella
AU - Buracchi, Chiara
AU - Savino, Benedetta
AU - Mantovani, Alberto
AU - Locati, Massimo
PY - 2008/7
Y1 - 2008/7
N2 - Chemokines are multifunctional molecules with roles in leukocyte trafficking and developmental processes. Both fetal and maternal components of the placenta produce chemokines, which control leukocyte trafficking observed in the placenta. Thus, chemokines play roles in the balance between protection of the developing embryo/fetus and tolerance of its hemiallogeneic tissues. Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as "silent" receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction. Here we review in vitro and in vivo evidence indicating that chemokine "silent" receptors regulate innate and adaptive immunity behaving as decoy receptors that support internalization and degradation of chemotactic factors, and discuss available information on their potential role in reproductive immunology.
AB - Chemokines are multifunctional molecules with roles in leukocyte trafficking and developmental processes. Both fetal and maternal components of the placenta produce chemokines, which control leukocyte trafficking observed in the placenta. Thus, chemokines play roles in the balance between protection of the developing embryo/fetus and tolerance of its hemiallogeneic tissues. Recently, a group of chemokine receptors, which include D6, DARC, and CCX-CKR, have been described as "silent" receptors by virtue of their inability to activate signal transduction events leading to cell chemoattraction. Here we review in vitro and in vivo evidence indicating that chemokine "silent" receptors regulate innate and adaptive immunity behaving as decoy receptors that support internalization and degradation of chemotactic factors, and discuss available information on their potential role in reproductive immunology.
KW - Chemokine
KW - Decoy receptor
KW - Inflammation
KW - Placenta
UR - http://www.scopus.com/inward/record.url?scp=50049104022&partnerID=8YFLogxK
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U2 - 10.1080/08820130802191318
DO - 10.1080/08820130802191318
M3 - Article
C2 - 18716935
AN - SCOPUS:50049104022
VL - 37
SP - 483
EP - 497
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 5-6
ER -