TY - JOUR
T1 - Chemokine decoy receptors
T2 - Structure-Function and biological properties
AU - Bonecchi, Raffaella
AU - Savino, Benedetta
AU - Borroni, Elena M.
AU - Mantovani, Alberto
AU - Locati, Massimo
PY - 2010
Y1 - 2010
N2 - Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
AB - Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
UR - http://www.scopus.com/inward/record.url?scp=78651249383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651249383&partnerID=8YFLogxK
U2 - 10.1007/82-2010-19
DO - 10.1007/82-2010-19
M3 - Article
C2 - 20373092
AN - SCOPUS:78651249383
VL - 341
SP - 15
EP - 36
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
SN - 0070-217X
IS - 1
ER -