Chemokine decoy receptors: Structure-Function and biological properties

Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.

Original languageEnglish
Pages (from-to)15-36
Number of pages22
JournalCurrent Topics in Microbiology and Immunology
Volume341
Issue number1
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

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