Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes

Jung Hwan Sung, Han Zhang, E. Ashley Moseman, David Alvarez, Matteo Iannacone, Sarah E. Henrickson, Juan C. De La Torre, Joanna R. Groom, Andrew D. Luster, Ulrich H. Von Andrian

Research output: Contribution to journalArticlepeer-review


A defining feature of vertebrate immunity is the acquisition of immunological memory, which confers enhanced protection against pathogens by mechanisms that are incompletely understood. Here, we compared responses by virus-specific naive T cells (TN) and central memory T cells (T CM) to viral antigen challenge in lymph nodes (LNs). In steady-state LNs, both T cell subsets localized in the deep T cell area and interacted similarly with antigen-presenting dendritic cells. However, upon entry of lymph-borne virus, only TCM relocalized rapidly and efficiently toward the outermost LN regions in the medullary, interfollicular, and subcapsular areas where viral infection was initially confined. This rapid peripheralization was coordinated by a cascade of cytokines and chemokines, particularly ligands for TCM-expressed CXCR3. Consequently, in vivo recall responses to viral infection by CXCR3-deficient TCM were markedly compromised, indicating that early antigen detection afforded by intranodal chemokine guidance of TCM is essential for efficient antiviral memory.

Original languageEnglish
Pages (from-to)1249-1263
Number of pages15
Issue number6
Publication statusPublished - Sep 14 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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