Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage

Anna Corcione, Nicoletta Arduino, Elisa Ferretti, Angela Pistorio, Monica Spinelli, Luciano Ottonello, Franco Dallegri, Giuseppe Basso, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

Scanty information is available on chemokine receptor expression and function in childhood B-lineage acute lymphoblastic leukemia (ALL). Thirteen pro-B, 17 early pre-B, 12 pre-B, and 9 B-ALL/Burkitt lymphoma (BL) pediatric cases were tested for CXCR1 to CXCR5 and CCR1 to CCR7 expression. CXCR2, CXCR3, and CXCR4 were expressed in the majority of cases, while the other receptors were variably expressed or absent. CXCR4 mediated chemotaxis of all leukemic cell subtypes. Freshly isolated CCR7+ early pre-B-ALL cells migrated to CCL19, whereas CCR7+ pro-B- and pre-B-ALL cells were attracted by CCL19 only following culture with soluble recombinant CD40 ligand.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalLeukemia Research
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2006

Keywords

  • B-lineage acute lymphoblastic leukemia
  • Chemokine receptors
  • Chemokines
  • Chemotaxis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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  • Cite this

    Corcione, A., Arduino, N., Ferretti, E., Pistorio, A., Spinelli, M., Ottonello, L., Dallegri, F., Basso, G., & Pistoia, V. (2006). Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage. Leukemia Research, 30(4), 365-372. https://doi.org/10.1016/j.leukres.2005.07.009