Chemokine regulation of neutrophil function in tumors

Ornella Bonavita, Matteo Massara, Raffaella Bonecchi

Research output: Contribution to journalArticle

Abstract

The role of neutrophils in cancer and metastasis is still debated and controversial since they have been shown to be endowed with both pro- and antitumor functions. These contradictory results seem to be now explained by recent discoveries of tumor-associated neutrophils plasticity and multiple neutrophil subsets.Chemokines and chemokine receptors are known to tightly regulate the release of neutrophils from the bone marrow, their passage into circulation and transmigration into the tissues as well as tumor infiltration. It is emerging that chemokine receptors are differentially expressed by neutrophil subsets and they affect not only their recruitment but also their effector functions.Here we are resuming human and murine data suggesting that therapeutic modulation of neutrophil activity through the targeting of specific chemokines or chemokine receptors can improve their anti-tumoral properties.

Original languageEnglish
JournalCytokine and Growth Factor Reviews
DOIs
Publication statusAccepted/In press - Mar 11 2016

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Keywords

  • Cancer
  • Chemokines
  • Inflammation
  • Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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