Chemokine system: New inflammatory markers on the horizon

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13 Citations (Scopus)

Abstract

Chemokines and their receptors direct cell migration in homeostatic and inflamed conditions, thus they are major players in key events of immune-mediated disorders. Indeed, much evidence indicates a non-redundant role of the chemokine system in several human diseases, ranging from classical immune-mediated pathologies, such as autoimmune and allergic diseases and transplant rejection, to neoplastic and vascular diseases. Increasing emerging evidence suggests the possible role of chemokines as biomarkers for monitoring disease activity, predicting relapses, monitoring surgical and pharmacological therapy and for providing prognostic indications. Several methods are now available for the detection and measurement of chemokines and their receptors in body fluids and tissues. The advantage of these assays is that they may be used in clinical laboratory and are directly applicable for biomedical diagnosis, representing a powerful tool which could dramatically improve screening, diagnosis and monitoring of diseases in the very near future.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalEuropean Journal of Inflammation
Volume8
Issue number1
Publication statusPublished - Jan 2010

Fingerprint

Chemokines
Chemokine Receptors
Immune System Diseases
Graft Rejection
Body Fluids
Vascular Diseases
Autoimmune Diseases
Cell Movement
Biomarkers
Pharmacology
Pathology
Recurrence
Therapeutics

Keywords

  • Chemokine
  • Chemokine receptors
  • Human diseases biomarkers

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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AB - Chemokines and their receptors direct cell migration in homeostatic and inflamed conditions, thus they are major players in key events of immune-mediated disorders. Indeed, much evidence indicates a non-redundant role of the chemokine system in several human diseases, ranging from classical immune-mediated pathologies, such as autoimmune and allergic diseases and transplant rejection, to neoplastic and vascular diseases. Increasing emerging evidence suggests the possible role of chemokines as biomarkers for monitoring disease activity, predicting relapses, monitoring surgical and pharmacological therapy and for providing prognostic indications. Several methods are now available for the detection and measurement of chemokines and their receptors in body fluids and tissues. The advantage of these assays is that they may be used in clinical laboratory and are directly applicable for biomedical diagnosis, representing a powerful tool which could dramatically improve screening, diagnosis and monitoring of diseases in the very near future.

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