Chemokines and bone remodeling

Research output: Contribution to journalArticlepeer-review


Bone remodeling is characterized by spatial and temporal coupling of bone resorption and formation and is necessary for skeletal growth and normal bone structure maintenance. Imbalance of this process is related to metabolic bone disorders such as osteoporosis or rheumatoid arthritis. For this reason, bone remodeling is under the control of several local and systemic factors, including molecules of the immune system. The importance of the interplay of both the skeletal and immune systems is reflected by the emerging interdisciplinary research field, called osteoimmunology, focused on common aspects of osteology and immunology. This review focuses on the role of inflammatory mediators, such as cytokines in bone remodeling and, in particular, a subfamily of chemotactic cytokines or chemokines which are involved not only in several aspects of physiological bone remodeling but also in pathological bone disorders, such as rheumatoid arthritis or osteoporosis. Understanding the role of inflammation and chemokines will provide new insights for the treatment of diseases affecting both skeletal and immune systems, by the development of new therapeutic strategies targeting common inflammatory mediators.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalInternational Journal of Immunopathology and Pharmacology
Issue number3
Publication statusPublished - Jul 2008


  • Bone remodeling
  • Chemokines
  • Cytokines
  • Osteoblasts
  • Osteoclasts

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy


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