Chemokines and chemokine receptors: An overview

Research output: Contribution to journalArticlepeer-review


Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

Original languageEnglish
Pages (from-to)540-551
Number of pages12
JournalFrontiers in Bioscience
Issue number2
Publication statusPublished - Jan 1 2009


  • Chemokine
  • Chemokine receptor
  • Inflammation
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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