Chemokines and chemokine receptors: An overview

Raffaella Bonecchi; Emanuela Galliera; Elena M. Borroni; Massimiliano M. Corsi; Massimo Locati; Alberto Mantovani

doi:10.2741/3261

Chemokines and chemokine receptors: An overview

Raffaella Bonecchi, Emanuela Galliera, Elena M. Borroni, Massimiliano M. Corsi, Massimo Locati, Alberto Mantovani

Research output: Contribution to journal › Article › peer-review

Abstract

Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.

Original language	English
Pages (from-to)	540-551
Number of pages	12
Journal	Frontiers in Bioscience
Volume	14
Issue number	2
DOIs	https://doi.org/10.2741/3261
Publication status	Published - Jan 1 2009

Keywords

Chemokine
Chemokine receptor
Inflammation
Review

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Medicine(all)

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10.2741/3261

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AU - Locati, Massimo

AU - Mantovani, Alberto

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Chemokines and chemokine receptors: An overview

Abstract

Keywords

ASJC Scopus subject areas

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