Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of th1 versus th2 responses

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Abstract

Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalInternational Journal of Clinical & Laboratory Research
Volume28
Issue number2
DOIs
Publication statusPublished - Jun 1998

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Chemokine Receptors
Chemokines
Dendritic Cells
Amplification
Monocytes
Chemical activation
Th2 Cells
Th1 Cells
Phagocytes
Leukocytes
Cytokines

Keywords

  • Chemokine receptors
  • Chemokines
  • Dendritic cells
  • Monocytes
  • Th1 and Th2 responses

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

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title = "Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of th1 versus th2 responses",
abstract = "Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.",
keywords = "Chemokine receptors, Chemokines, Dendritic cells, Monocytes, Th1 and Th2 responses",
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T1 - Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of th1 versus th2 responses

AU - Mantovani, A.

AU - Allavena, P.

AU - Vecchi, A.

AU - Sozzani, S.

PY - 1998/6

Y1 - 1998/6

N2 - Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.

AB - Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.

KW - Chemokine receptors

KW - Chemokines

KW - Dendritic cells

KW - Monocytes

KW - Th1 and Th2 responses

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