Abstract
Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.
Original language | English |
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Pages (from-to) | 77-82 |
Number of pages | 6 |
Journal | International Journal of Clinical & Laboratory Research |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jun 1998 |
Keywords
- Chemokine receptors
- Chemokines
- Dendritic cells
- Monocytes
- Th1 and Th2 responses
ASJC Scopus subject areas
- Clinical Biochemistry