Abstract
Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.
| Original language | English |
|---|---|
| Pages (from-to) | 77-82 |
| Number of pages | 6 |
| Journal | International Journal of Clinical & Laboratory Research |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1998 |
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Keywords
- Chemokine receptors
- Chemokines
- Dendritic cells
- Monocytes
- Th1 and Th2 responses
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of th1 versus th2 responses. / Mantovani, A.; Allavena, P.; Vecchi, A.; Sozzani, S.
In: International Journal of Clinical & Laboratory Research, Vol. 28, No. 2, 06.1998, p. 77-82.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of th1 versus th2 responses
AU - Mantovani, A.
AU - Allavena, P.
AU - Vecchi, A.
AU - Sozzani, S.
PY - 1998/6
Y1 - 1998/6
N2 - Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.
AB - Chemokines are a superfamily of small cytokines which are generally chemotactic for leukocytes. The general features of chemokines and their receptors are reviewed. Recent evidence indicates that receptor expression dictates the spectrum of action of chemokines, as shown recently for Th1 and Th2 cells. Chemokines represent amplification loops of polarized Th1 and Th2 responses. Receptor expression is tightly regulated during differentiation, activation, and deactivation of mononuclear phagocytes and dendritic cells. Thus, regulation of receptor expression is crucial as a set point of the chemokine system.
KW - Chemokine receptors
KW - Chemokines
KW - Dendritic cells
KW - Monocytes
KW - Th1 and Th2 responses
UR - http://www.scopus.com/inward/record.url?scp=0031828647&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031828647&partnerID=8YFLogxK
U2 - 10.1007/s005990050023
DO - 10.1007/s005990050023
M3 - Article
VL - 28
SP - 77
EP - 82
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 2
ER -