Chemokines and NK cells: Regulators of development, trafficking and functions

Giovanni Bernardini, Angela Gismondi, Angela Santoni

Research output: Contribution to journalArticle

Abstract

NK cells are innate lymphocytes capable of killing malignant or infected cells and to produce a wide array of cytokines and chemokines following activation.Chemokines, play critical roles in the regulation of NK cell tissue distribution in normal conditions as well as their rapid recruitment to the parenchyma of injured organs during inflammation, which is critical for NK cell ability to promote protective responses. In this regard, differences in chemokine receptor expression have been reported on specialized NK cell subsets with distinct effector functions and tissue distribution.Besides their role in the regulation of NK cell trafficking, chemotactic molecules can also affect NK cell effector functions by regulating their priming and their ability to kill and secrete cytokines.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalImmunology Letters
Volume145
Issue number1-2
DOIs
Publication statusPublished - Jul 30 2012

Fingerprint

Chemokines
Natural Killer Cells
Tissue Distribution
Cytokines
Chemokine Receptors
Lymphocytes
Inflammation

Keywords

  • Chemokine receptors
  • Chemokines
  • Chemotaxis
  • Lymphocyte homing
  • NK cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Chemokines and NK cells : Regulators of development, trafficking and functions. / Bernardini, Giovanni; Gismondi, Angela; Santoni, Angela.

In: Immunology Letters, Vol. 145, No. 1-2, 30.07.2012, p. 39-46.

Research output: Contribution to journalArticle

Bernardini, Giovanni ; Gismondi, Angela ; Santoni, Angela. / Chemokines and NK cells : Regulators of development, trafficking and functions. In: Immunology Letters. 2012 ; Vol. 145, No. 1-2. pp. 39-46.
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