Chemokines and their receptors: Drug targets in immunity and inflammation

Antonella Viola, Andrew D. Luster

Research output: Contribution to journalArticle

Abstract

The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases. Although several successful strategies have been identified to develop drugs targeting chemokines and their receptors, this has not yet resulted in many new therapeutics. This is likely due to a complexity of the chemokine system, which was not initially appreciated, that is characterized by redundancy, pleiotropy, and differences among species. Nevertheless, our understanding of chemokine biology is continuing to grow and several promising drugs are currently being tested in late-stage clinical trials. In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system.

Original languageEnglish
Pages (from-to)171-197
Number of pages27
JournalAnnual Review of Pharmacology and Toxicology
Volume48
DOIs
Publication statusPublished - 2008

Keywords

  • Chemotaxis
  • Disease
  • Drug discovery
  • Leukocytes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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