Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis

Research output: Contribution to journalArticlepeer-review

Abstract

Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration-based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et al. [Eur. J. Immunol. 2015. 45: 101-112] show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte-derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1α for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalEuropean Journal of Immunology
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Chemokines
  • Chemotaxis
  • Dendritic cells
  • Migration
  • Monocytes
  • Serum amyloid A

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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