Chemokines in cancer related inflammation

Research output: Contribution to journalArticle

Abstract

Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

Original languageEnglish
Pages (from-to)664-673
Number of pages10
JournalExperimental Cell Research
Volume317
Issue number5
DOIs
Publication statusPublished - Mar 10 2011

Keywords

  • Cancer
  • Chemokines
  • Inflammation
  • Macrophages
  • Receptors

ASJC Scopus subject areas

  • Cell Biology

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