Chemokines in leukocyte recruitment: Cellular targets and signal transduction

S. Sozzani, M. Romano, M. Locati, W. Luini, A. Borsatti, S. Bernasconi, P. Allavena, A. Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines are a bipartite family of chemotactic proteins which bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of chemokines encompasses a large number of leukocyte populations, including monocytes, granolocytes, lymphocytes, NK and dendritic cells. Although the spectrum of action of chemokines largely overlaps clear differences are still present. Chemokines play an important role in the recruitment of leukocytes at the site of inflammation, allergic reaction and tumors. Recent studies performed with IL-6-/- mice have shown a peculiar positive interaction between IL-6 and chemokines in a model of local inflammation in vivo. Available information on receptor usage by MCP-1 and related chemokines and signal transduction patway will be reviewed. The better understanding of signaling mechanisms will provide a new basis to develop therapeutic strategies.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalPeriodicum Biologorum
Volume98
Issue number4
Publication statusPublished - 1996

Keywords

  • Leukocyte recruitment
  • MCP-1 tumor derived chemotactic chemokine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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