Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalSeminars in Cancer Biology
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Chemokines
Leukocytes
Neoplasms
Macrophages
Dendritic Cells
Growth
Population

Keywords

  • Chemokines
  • Infiltrating leukocytes
  • Recruitment

ASJC Scopus subject areas

  • Cancer Research

Cite this

@article{24e109b7c1744107b4482cd0063340ce,
title = "Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors",
abstract = "Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.",
keywords = "Chemokines, Infiltrating leukocytes, Recruitment",
author = "Alberto Mantovani and Paola Allavena and Silvano Sozzani and Annunciata Vecchi and Massimo Locati and Antonio Sica",
year = "2004",
month = "6",
doi = "10.1016/j.semcancer.2003.10.001",
language = "English",
volume = "14",
pages = "155--160",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press",
number = "3",

}

TY - JOUR

T1 - Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

AU - Mantovani, Alberto

AU - Allavena, Paola

AU - Sozzani, Silvano

AU - Vecchi, Annunciata

AU - Locati, Massimo

AU - Sica, Antonio

PY - 2004/6

Y1 - 2004/6

N2 - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

AB - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

KW - Chemokines

KW - Infiltrating leukocytes

KW - Recruitment

UR - http://www.scopus.com/inward/record.url?scp=2342565892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342565892&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2003.10.001

DO - 10.1016/j.semcancer.2003.10.001

M3 - Article

C2 - 15246050

AN - SCOPUS:2342565892

VL - 14

SP - 155

EP - 160

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

IS - 3

ER -