Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Research output: Contribution to journalArticle

Abstract

Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalSeminars in Cancer Biology
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Chemokines
  • Infiltrating leukocytes
  • Recruitment

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors'. Together they form a unique fingerprint.

  • Cite this