Chemokines sound the alarmin: The role of atypical chemokine in inflammation and cancer

Research output: Contribution to journalReview article

Abstract

As main drivers of leukocyte recruitment during inflammatory reactions, chemokines act as mediatrs of alarmins in priming host defense responses after tissue exposure to toxic or infectious agents, immunomediated damage, and in inflammation-driven tumors. Chemokines can therefore be considered alarm signals generated by tissues in a broad number of conditions, and mechanisms controlling chemokines biological activities are therefore key to regulate tissue reactions induced by alarmins. By transporting, presenting or scavenging different sets of chemokines, atypical chemokine receptors represent an emerign subfamily of chemokine receptors which operates in tissues as chemokine gatekeepers in order to establish and shape their gradients and coordinate leukocyte recruitment.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalSeminars in Immunology
Volume38
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • Atypical chemokine receptors
  • Cancer related inflammation
  • Chemokines
  • Scavenger receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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