Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

Roberto Gerli, Daniela Monti, Onelia Bistoni, Anna M. Mazzone, Giuseppe Peri, Andrea Cossarizza, Mario Di Gioacchino, Monica E. F. Cesarotti, Andrea Doni, Alberto Mantovani, Claudio Franceschi, Roberto Paganelli

Research output: Contribution to journalArticle

Abstract

Several lines of evidence point to a profound remodelling of the cytokine network in healthy elderly subjects, with decreased type-1 cytokine production (IL 2) and a shift to type 0 and 2. We have also observed an increase of proinflammatory cytokines (IL-1, IL-6, TNF-α) in vitro, and an increase of circulating stem cell factor in vivo. In this setting, we studied changes of chemokines (MCP-1 and RANTES) with aging, as well as other molecules, namely, sTNF-RI and sTNF-RII, and the soluble form of the CD30 molecule (sCD30), involved in the pro- and antiinflammatory cytokine balance. The subjects enrolled in the study belonged to three different selected healthy groups of young, aged and centenarians. The presence of rheumatoid factor (RF) and antinuclear antibodies (ANA) was simultaneously assessed. The results show that MCP-1 serum levels were higher in the healthy aged and lowest in the young, while RANTES increased exclusively in centenarians. Only centenarians had autoantibodies (ANA and RF). sTNF-RI and sTNF-RII were significantly elevated in healthy old subjects compared to the young, and even higher in selected centenarians compared to the other age groups. sCD30 serum levels were significantly raised in centenarians compared to the young, despite absence of circulating CD30+ cells in the peripheral blood of the whole study population. No relationship among serum values of these different members of the TNF-R family was found, despite a strong correlation for sTNF-RI and sTNF-RII in all groups. We hypothesize that the increased chemokine levels in aged people, and raised sCD30 levels in centenarians, may reflect a general shift towards type 0/2 cytokines in normal aging, which may be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalMechanisms of Ageing and Development
Volume121
Issue number1-3
DOIs
Publication statusPublished - Jan 20 2001

Fingerprint

Chemokines
Cytokines
Antinuclear Antibodies
Chemokine CCL5
Serum
Rheumatoid Factor
Autoantibodies
Aging of materials
Healthy Volunteers
Molecules
Stem Cell Factor
Interleukin-1
Interleukin-2
Interleukin-6
Blood
Anti-Inflammatory Agents
Age Groups
Population

Keywords

  • Antinuclear antibodies
  • Chemokines
  • Cytokine network
  • Proinflammatory cytokines
  • Rheumatoid factor
  • Soluble receptors

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., ... Paganelli, R. (2001). Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mechanisms of Ageing and Development, 121(1-3), 37-46. https://doi.org/10.1016/S0047-6374(00)00195-0

Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. / Gerli, Roberto; Monti, Daniela; Bistoni, Onelia; M. Mazzone, Anna; Peri, Giuseppe; Cossarizza, Andrea; Di Gioacchino, Mario; E. F. Cesarotti, Monica; Doni, Andrea; Mantovani, Alberto; Franceschi, Claudio; Paganelli, Roberto.

In: Mechanisms of Ageing and Development, Vol. 121, No. 1-3, 20.01.2001, p. 37-46.

Research output: Contribution to journalArticle

Gerli, R, Monti, D, Bistoni, O, M. Mazzone, A, Peri, G, Cossarizza, A, Di Gioacchino, M, E. F. Cesarotti, M, Doni, A, Mantovani, A, Franceschi, C & Paganelli, R 2001, 'Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians', Mechanisms of Ageing and Development, vol. 121, no. 1-3, pp. 37-46. https://doi.org/10.1016/S0047-6374(00)00195-0
Gerli, Roberto ; Monti, Daniela ; Bistoni, Onelia ; M. Mazzone, Anna ; Peri, Giuseppe ; Cossarizza, Andrea ; Di Gioacchino, Mario ; E. F. Cesarotti, Monica ; Doni, Andrea ; Mantovani, Alberto ; Franceschi, Claudio ; Paganelli, Roberto. / Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. In: Mechanisms of Ageing and Development. 2001 ; Vol. 121, No. 1-3. pp. 37-46.
@article{acf466820685477bb8f3c6a710b41d2c,
title = "Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians",
abstract = "Several lines of evidence point to a profound remodelling of the cytokine network in healthy elderly subjects, with decreased type-1 cytokine production (IL 2) and a shift to type 0 and 2. We have also observed an increase of proinflammatory cytokines (IL-1, IL-6, TNF-α) in vitro, and an increase of circulating stem cell factor in vivo. In this setting, we studied changes of chemokines (MCP-1 and RANTES) with aging, as well as other molecules, namely, sTNF-RI and sTNF-RII, and the soluble form of the CD30 molecule (sCD30), involved in the pro- and antiinflammatory cytokine balance. The subjects enrolled in the study belonged to three different selected healthy groups of young, aged and centenarians. The presence of rheumatoid factor (RF) and antinuclear antibodies (ANA) was simultaneously assessed. The results show that MCP-1 serum levels were higher in the healthy aged and lowest in the young, while RANTES increased exclusively in centenarians. Only centenarians had autoantibodies (ANA and RF). sTNF-RI and sTNF-RII were significantly elevated in healthy old subjects compared to the young, and even higher in selected centenarians compared to the other age groups. sCD30 serum levels were significantly raised in centenarians compared to the young, despite absence of circulating CD30+ cells in the peripheral blood of the whole study population. No relationship among serum values of these different members of the TNF-R family was found, despite a strong correlation for sTNF-RI and sTNF-RII in all groups. We hypothesize that the increased chemokine levels in aged people, and raised sCD30 levels in centenarians, may reflect a general shift towards type 0/2 cytokines in normal aging, which may be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age.",
keywords = "Antinuclear antibodies, Chemokines, Cytokine network, Proinflammatory cytokines, Rheumatoid factor, Soluble receptors",
author = "Roberto Gerli and Daniela Monti and Onelia Bistoni and {M. Mazzone}, Anna and Giuseppe Peri and Andrea Cossarizza and {Di Gioacchino}, Mario and {E. F. Cesarotti}, Monica and Andrea Doni and Alberto Mantovani and Claudio Franceschi and Roberto Paganelli",
year = "2001",
month = "1",
day = "20",
doi = "10.1016/S0047-6374(00)00195-0",
language = "English",
volume = "121",
pages = "37--46",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "1-3",

}

TY - JOUR

T1 - Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

AU - Gerli, Roberto

AU - Monti, Daniela

AU - Bistoni, Onelia

AU - M. Mazzone, Anna

AU - Peri, Giuseppe

AU - Cossarizza, Andrea

AU - Di Gioacchino, Mario

AU - E. F. Cesarotti, Monica

AU - Doni, Andrea

AU - Mantovani, Alberto

AU - Franceschi, Claudio

AU - Paganelli, Roberto

PY - 2001/1/20

Y1 - 2001/1/20

N2 - Several lines of evidence point to a profound remodelling of the cytokine network in healthy elderly subjects, with decreased type-1 cytokine production (IL 2) and a shift to type 0 and 2. We have also observed an increase of proinflammatory cytokines (IL-1, IL-6, TNF-α) in vitro, and an increase of circulating stem cell factor in vivo. In this setting, we studied changes of chemokines (MCP-1 and RANTES) with aging, as well as other molecules, namely, sTNF-RI and sTNF-RII, and the soluble form of the CD30 molecule (sCD30), involved in the pro- and antiinflammatory cytokine balance. The subjects enrolled in the study belonged to three different selected healthy groups of young, aged and centenarians. The presence of rheumatoid factor (RF) and antinuclear antibodies (ANA) was simultaneously assessed. The results show that MCP-1 serum levels were higher in the healthy aged and lowest in the young, while RANTES increased exclusively in centenarians. Only centenarians had autoantibodies (ANA and RF). sTNF-RI and sTNF-RII were significantly elevated in healthy old subjects compared to the young, and even higher in selected centenarians compared to the other age groups. sCD30 serum levels were significantly raised in centenarians compared to the young, despite absence of circulating CD30+ cells in the peripheral blood of the whole study population. No relationship among serum values of these different members of the TNF-R family was found, despite a strong correlation for sTNF-RI and sTNF-RII in all groups. We hypothesize that the increased chemokine levels in aged people, and raised sCD30 levels in centenarians, may reflect a general shift towards type 0/2 cytokines in normal aging, which may be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age.

AB - Several lines of evidence point to a profound remodelling of the cytokine network in healthy elderly subjects, with decreased type-1 cytokine production (IL 2) and a shift to type 0 and 2. We have also observed an increase of proinflammatory cytokines (IL-1, IL-6, TNF-α) in vitro, and an increase of circulating stem cell factor in vivo. In this setting, we studied changes of chemokines (MCP-1 and RANTES) with aging, as well as other molecules, namely, sTNF-RI and sTNF-RII, and the soluble form of the CD30 molecule (sCD30), involved in the pro- and antiinflammatory cytokine balance. The subjects enrolled in the study belonged to three different selected healthy groups of young, aged and centenarians. The presence of rheumatoid factor (RF) and antinuclear antibodies (ANA) was simultaneously assessed. The results show that MCP-1 serum levels were higher in the healthy aged and lowest in the young, while RANTES increased exclusively in centenarians. Only centenarians had autoantibodies (ANA and RF). sTNF-RI and sTNF-RII were significantly elevated in healthy old subjects compared to the young, and even higher in selected centenarians compared to the other age groups. sCD30 serum levels were significantly raised in centenarians compared to the young, despite absence of circulating CD30+ cells in the peripheral blood of the whole study population. No relationship among serum values of these different members of the TNF-R family was found, despite a strong correlation for sTNF-RI and sTNF-RII in all groups. We hypothesize that the increased chemokine levels in aged people, and raised sCD30 levels in centenarians, may reflect a general shift towards type 0/2 cytokines in normal aging, which may be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age.

KW - Antinuclear antibodies

KW - Chemokines

KW - Cytokine network

KW - Proinflammatory cytokines

KW - Rheumatoid factor

KW - Soluble receptors

UR - http://www.scopus.com/inward/record.url?scp=0035915808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035915808&partnerID=8YFLogxK

U2 - 10.1016/S0047-6374(00)00195-0

DO - 10.1016/S0047-6374(00)00195-0

M3 - Article

C2 - 11164458

AN - SCOPUS:0035915808

VL - 121

SP - 37

EP - 46

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 1-3

ER -