Chemoprevention is a promising strategy for reducing human cancer incidence and mortality. This preventive approach is based on the control of carcinogenesis through long term administration of safe dietetic or not dietetic substances. The target population is mostly represented by high-risk groups such as survivors of primary cancers or subjects with premalignant conditions or genetically predisposed to the development of cancer. Several agents are tested in phase II/III chemoprevention trials in different tumors or precancerous lesions of the gastrointestinal tract, with particular attention to oropharynx, stomach and colon. These substances are retinoids, β-carotene, ascorbic acid, tocopherol, agents related with diet such as calcium and some fibers and some nonsteroidal antiinflammatory drugs (i.e. sulindac and aspirin).
|Translated title of the contribution||Chemoprevention in digestive cancer|
|Number of pages||11|
|Journal||Giornale Italiano di Endoscopia Digestiva|
|Publication status||Published - 1995|
ASJC Scopus subject areas