LA CHEMIOPREVENZIONE NEI TUMORI DIGESTIVI

Translated title of the contribution: Chemoprevention in digestive cancer

A. Giacosa, R. Filiberti, L. Borsa

Research output: Contribution to journalArticle

Abstract

Chemoprevention is a promising strategy for reducing human cancer incidence and mortality. This preventive approach is based on the control of carcinogenesis through long term administration of safe dietetic or not dietetic substances. The target population is mostly represented by high-risk groups such as survivors of primary cancers or subjects with premalignant conditions or genetically predisposed to the development of cancer. Several agents are tested in phase II/III chemoprevention trials in different tumors or precancerous lesions of the gastrointestinal tract, with particular attention to oropharynx, stomach and colon. These substances are retinoids, β-carotene, ascorbic acid, tocopherol, agents related with diet such as calcium and some fibers and some nonsteroidal antiinflammatory drugs (i.e. sulindac and aspirin).

Translated title of the contributionChemoprevention in digestive cancer
Original languageItalian
Pages (from-to)135-145
Number of pages11
JournalGiornale Italiano di Endoscopia Digestiva
Volume18
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Gastroenterology

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