Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma

Gian Carlo Mattiucci, Rosa Autorino, Giuseppe Roberto D'Agostino, Francesco Deodato, Gabriella Macchia, Vincenzo Perri, Andrea Tringali, Alessio Giuseppe Morganti, Massimiliano Mutignani, Vincenzo Valentini

Research output: Contribution to journalArticle


Background: To explore the role of radiotherapy in the extrahepatic bile duct carcinoma, and to understand if and when radiotherapy could be effective for this group of patients. Methods: A systematic review of recently published literature was completed. Recent studies using radiotherapy with survival data, resection rates and quality of life data have been analyzed. Results: There are no randomized trials regarding the treatment of extrahepatic cholangiocarcinoma. The bulk of available studies suggest that in some cases radio-chemotherapy can be used as adjuvant therapy. Radiotherapy could also have a role in unresectable cholangiocarcinoma: external radiotherapy or intraluminal brachytherapy - alone or in combination - could improve the outcome in selected patients.Finally, radiotherapy, and in particular intraluminal brachytherapy, could be used as a palliative treatment to improve the quality of life and in controlling symptoms. Conclusion: The role of radiotherapy in extrahepatic cholangiocarcinoma remains undefined due to the lack of randomized trials or otherwise properly controlled studies.

Original languageEnglish
Pages (from-to)58-67
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Issue number1
Publication statusPublished - 2014



  • Brachytherapy
  • Intraoperative radiotherapy
  • Palliative therapy
  • Radio-chemotherapy
  • Resectable cholangiocarcinoma
  • Unresectable cholangiocarcinoma

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Mattiucci, G. C., Autorino, R., D'Agostino, G. R., Deodato, F., Macchia, G., Perri, V., Tringali, A., Morganti, A. G., Mutignani, M., & Valentini, V. (2014). Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma. Critical Reviews in Oncology/Hematology, 90(1), 58-67.