Chemotactic cytokine gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

Walter Luini, Marco De Rossi, Luciano Licciardello, Francesco Colotta, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on production of the chemotactic cytokine, IL-8, and monocyte chemotactic protein (MCP) by human peripheral blood monocytes. Exposure of human peripheral blood monocytes to MPG in vitro induced high levels of mRNA transcripts for IL-8 and MCP, as assessed by Northern blot analysis. Cytokine gene expression was associated with the production of chemotactic activity in the supernatants. The levels of IL-8 and MCP expression induced by MPG were comparable with those elicited by LPS. Induction of chemotactic cytokines in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume13
Issue number6
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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