Chemotherapy and skin reactions

Gabriella Fabbrocini, Norma Cameli, Maria Concetta Romano, Maria Mariano, Luigia Panariello, Dario Bianca, Giuseppe Monfrecola

Research output: Contribution to journalArticlepeer-review


Background: New chemotherapic agents and new protocols in oncology have led to an increasing survival rate in patients affected by tumors. However, this increased use has been accompanied by a growth in the incidence of cutaneous side effects and a worsening of patients quality of life. Appropriate management of skin toxicity associated with chemotherapic agents is therefore necessary for suitable drug administration and to improve quality of life and clinical outcomes. Methods: We have clinically examined 100 patients affected by cancer, determining type, frequency, treatment, and evolution of side effects related to chemotherapy. Results: The prevalent cutaneous side effects in patients undergoing chemotherapy are skin rash, xerosis, pruritus, paronychia, hair abnormality, and mucositis. The clinical cases are reported in detail. Conclusion: Oncological therapies have become more selective and have low systemic toxicity because of their high specificity, but cutaneous side effects are common and may worsen the quality of life of these patients.

Original languageEnglish
Article number50
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
Publication statusPublished - 2012


  • Anti-EGF
  • Chemotherapy
  • Follicular rash
  • Paronychia
  • Skin toxicity
  • Xerosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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