Abstract
The majority of optic pathway tumors associated with Neurofibromatosis type-1 (NF-1) are benign, slow-growing lesions: however, rapidly growing tumors, which cause proptosis and visual loss, can sometimes occur. Optimal management of these tumors is still unclear. We report the case of a 12-year-old male, affected by NF-1 who was found to have a rapidly growing right optic nerve glioma, treated with carboplatin and vincristine. During chemotherapy, optic disc swelling rapidly disappeared; the orbital tumor decreased in size, with magnetic resonance imaging (MRI) evidence of tumor shrinkage. There was a progressive improvement in visual acuity and Visually Evoked Potential (VEP) amplitudes. Children with NF-1 associated optic pathway tumors should not receive chemotherapy unless there is documented progressive disease. Nevertheless, in contrast with previous studies, this case demonstrates that chemotherapy can be a safe and effective treatment for NF-1-associated optic nerve glioma, and should not be reserved only for patients with optic chiasm or tract involvement.
| Original language | English |
|---|---|
| Pages (from-to) | 159-162 |
| Number of pages | 4 |
| Journal | Neuro-Ophthalmology |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Chemotherapy
- Glioma
- Neurofibromatosis
- Optic nerve
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology
Cite this
Chemotherapy for optic nerve glioma in a child with neurofibromatosis type-1. / Parentin, Fulvio; Rabusin, Marco; Zennaro, Floriana; Orth, Dario Catalano; Pensiero, Stefano.
In: Neuro-Ophthalmology, Vol. 32, No. 3, 06.2008, p. 159-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemotherapy for optic nerve glioma in a child with neurofibromatosis type-1
AU - Parentin, Fulvio
AU - Rabusin, Marco
AU - Zennaro, Floriana
AU - Orth, Dario Catalano
AU - Pensiero, Stefano
PY - 2008/6
Y1 - 2008/6
N2 - The majority of optic pathway tumors associated with Neurofibromatosis type-1 (NF-1) are benign, slow-growing lesions: however, rapidly growing tumors, which cause proptosis and visual loss, can sometimes occur. Optimal management of these tumors is still unclear. We report the case of a 12-year-old male, affected by NF-1 who was found to have a rapidly growing right optic nerve glioma, treated with carboplatin and vincristine. During chemotherapy, optic disc swelling rapidly disappeared; the orbital tumor decreased in size, with magnetic resonance imaging (MRI) evidence of tumor shrinkage. There was a progressive improvement in visual acuity and Visually Evoked Potential (VEP) amplitudes. Children with NF-1 associated optic pathway tumors should not receive chemotherapy unless there is documented progressive disease. Nevertheless, in contrast with previous studies, this case demonstrates that chemotherapy can be a safe and effective treatment for NF-1-associated optic nerve glioma, and should not be reserved only for patients with optic chiasm or tract involvement.
AB - The majority of optic pathway tumors associated with Neurofibromatosis type-1 (NF-1) are benign, slow-growing lesions: however, rapidly growing tumors, which cause proptosis and visual loss, can sometimes occur. Optimal management of these tumors is still unclear. We report the case of a 12-year-old male, affected by NF-1 who was found to have a rapidly growing right optic nerve glioma, treated with carboplatin and vincristine. During chemotherapy, optic disc swelling rapidly disappeared; the orbital tumor decreased in size, with magnetic resonance imaging (MRI) evidence of tumor shrinkage. There was a progressive improvement in visual acuity and Visually Evoked Potential (VEP) amplitudes. Children with NF-1 associated optic pathway tumors should not receive chemotherapy unless there is documented progressive disease. Nevertheless, in contrast with previous studies, this case demonstrates that chemotherapy can be a safe and effective treatment for NF-1-associated optic nerve glioma, and should not be reserved only for patients with optic chiasm or tract involvement.
KW - Chemotherapy
KW - Glioma
KW - Neurofibromatosis
KW - Optic nerve
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U2 - 10.1080/01658100802115163
DO - 10.1080/01658100802115163
M3 - Article
VL - 32
SP - 159
EP - 162
JO - Neuro-Ophthalmology
JF - Neuro-Ophthalmology
SN - 0165-8107
IS - 3
ER -