Chemotherapy for optic nerve glioma in a child with neurofibromatosis type-1

Fulvio Parentin, Marco Rabusin, Floriana Zennaro, Dario Catalano Orth, Stefano Pensiero

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The majority of optic pathway tumors associated with Neurofibromatosis type-1 (NF-1) are benign, slow-growing lesions: however, rapidly growing tumors, which cause proptosis and visual loss, can sometimes occur. Optimal management of these tumors is still unclear. We report the case of a 12-year-old male, affected by NF-1 who was found to have a rapidly growing right optic nerve glioma, treated with carboplatin and vincristine. During chemotherapy, optic disc swelling rapidly disappeared; the orbital tumor decreased in size, with magnetic resonance imaging (MRI) evidence of tumor shrinkage. There was a progressive improvement in visual acuity and Visually Evoked Potential (VEP) amplitudes. Children with NF-1 associated optic pathway tumors should not receive chemotherapy unless there is documented progressive disease. Nevertheless, in contrast with previous studies, this case demonstrates that chemotherapy can be a safe and effective treatment for NF-1-associated optic nerve glioma, and should not be reserved only for patients with optic chiasm or tract involvement.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalNeuro-Ophthalmology
Volume32
Issue number3
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Optic Nerve Glioma
Neurofibromatosis 1
Drug Therapy
Neoplasms
Optic Chiasm
Exophthalmos
Carboplatin
Optic Disk
Vincristine
Evoked Potentials
Visual Acuity
Magnetic Resonance Imaging

Keywords

  • Chemotherapy
  • Glioma
  • Neurofibromatosis
  • Optic nerve

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

Cite this

Chemotherapy for optic nerve glioma in a child with neurofibromatosis type-1. / Parentin, Fulvio; Rabusin, Marco; Zennaro, Floriana; Orth, Dario Catalano; Pensiero, Stefano.

In: Neuro-Ophthalmology, Vol. 32, No. 3, 06.2008, p. 159-162.

Research output: Contribution to journalArticle

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