Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates

M. Sironi, M. A. Canegrati, M. Romano, A. Vecchi, F. Spreafico

Research output: Contribution to journalArticle


A model employing murine L 1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalCancer Treatment Reports
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Sironi, M., Canegrati, M. A., Romano, M., Vecchi, A., & Spreafico, F. (1984). Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates. Cancer Treatment Reports, 68(4), 643-645.