Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates

M. Sironi, M. A. Canegrati, M. Romano, A. Vecchi, F. Spreafico

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A model employing murine L 1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalCancer Treatment Reports
Volume68
Issue number4
Publication statusPublished - 1984

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Immunotoxins
Antineoplastic Agents
Drug Therapy
Ricin
Leukemia L1210
Therapeutics
Anti-Idiotypic Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sironi, M., Canegrati, M. A., Romano, M., Vecchi, A., & Spreafico, F. (1984). Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates. Cancer Treatment Reports, 68(4), 643-645.

Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates. / Sironi, M.; Canegrati, M. A.; Romano, M.; Vecchi, A.; Spreafico, F.

In: Cancer Treatment Reports, Vol. 68, No. 4, 1984, p. 643-645.

Research output: Contribution to journalArticle

Sironi, M, Canegrati, MA, Romano, M, Vecchi, A & Spreafico, F 1984, 'Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates', Cancer Treatment Reports, vol. 68, no. 4, pp. 643-645.
Sironi M, Canegrati MA, Romano M, Vecchi A, Spreafico F. Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates. Cancer Treatment Reports. 1984;68(4):643-645.
Sironi, M. ; Canegrati, M. A. ; Romano, M. ; Vecchi, A. ; Spreafico, F. / Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates. In: Cancer Treatment Reports. 1984 ; Vol. 68, No. 4. pp. 643-645.
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