Chemotherapy-induced anemia in breast cancer patients treated with pegfilgrastim-supported dose-dense regimens

Mariangela Manzoni, Sara Delfanti, Bianca Rovati, Donatella Grasso, Sara Mariucci, Katia Bencardino, Carmine Tinelli, Marco Danova

Research output: Contribution to journalArticlepeer-review

Abstract

The primary use of recombinant granulocyte colony-stimulating factors has reduced the incidence of febrile neutropenia during dose-dense adjuvant/neoadjuvant chemotherapy programs for breast cancer. Otherwise, in this population, filgrastim seems to worse chemotherapy- induced anemia, especially when administered with prolonged schedules that induced leukocytosis. No exhaustive data are available about the effect of longlasting formulation of filgrastim (pegfilgrastim) on hemoglobin levels. We retrospectively analyzed the data regarding hemoglobin level and leukocyte count of 38 breast cancer patients treated with dose-dense anthacycline and/or taxane-based chemotherapy with pegfilgrastim support, both in adjuvant and in neoadjuvant settings. Mean hemoglobin levels progressively decreased throughout the treatment (without correlation with both the schedule of chemotherapy and the patient's age) but only two patients developed mild anemia. No significant correlation was found between the degree of leukocytosis and the hemoglobin decrease. These data suggest that pegfilgrastim, per se, doesn't seem to worse chemotherapyinduced anemia. This fact may be at least in part explains by its ''balanced" impact on hematopoietic recovery during dose-dense chemotherapy.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalClinical and Experimental Medicine
Volume10
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Anemia
  • Breast cancer
  • Dose-dense chemotherapy
  • Pegfilgrastim

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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