Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: A study of preoperative treatment

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Abstract

Purpose: The purpose of this research was to identify factors predicting response to preoperative chemotherapy. Experimental Design: In a large volume laboratory using standard immunohistochemical methods, we reviewed the pretreatment biopsies and histologic specimens at final surgery of 399 patients with large or locally advanced breast cancer (cT2-T4, N0-2, M0) who were treated with preoperative chemotherapy. The incidence of pathological complete remission and the incidence of node-negative status at final surgery were assessed with respect to initial pathological and clinical findings. Menopausal status, estrogen receptor status, progesterone receptor status [absent (0% of the cells positive) versus expressed], clinical tumor size, histologic grade, Ki-67, Her-2/neu expression, and type and route of chemotherapy were considered. Results: High rates of pathological complete remission were associated with absence of estrogen receptor and progesterone receptor expression (P <0.0001), and grade 3 (P = 0.001). Significant predictors of node-negative status at surgery were absence of estrogen receptor and progesterone receptor expression (P <0.0001), clinical tumor size

Original languageEnglish
Pages (from-to)6622-6628
Number of pages7
JournalClinical Cancer Research
Volume10
Issue number19
DOIs
Publication statusPublished - Oct 1 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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