Chemotherapy with Epirubicin and Paclitaxel for Breast Cancer during Pregnancy: Case Report and Review of the Literature

Angiolo Gadducci, Stefania Cosio, Antonio Fanucchi, Vincenzo Nardini, Manuela Roncella, Pier Franco Conte, Andrea Riccardo Genazzani

Research output: Contribution to journalArticle

Abstract

Background: Breast cancer diagnosed during pregnancy is a challenging clinical situation. Little data are currently available about chemotherapy in pregnant women with this malignancy. Case Report: We report the case of a 36-year-old pregnant woman with a T2N1M0 breast cancer who received sequential chemotherapy including epirubicin (120 mg/m2 every three weeks for four cycles) and paclitaxel (175 mg/m2 every three weeks for three cycles) from the 14th to the 32th week of gestation. The patient delivered a normal female baby by caesarean section at the 36th week. The immunohistochemical examination of the placenta showed a diffuse, strong P-glycoprotein expression. Thirty-six months after the delivery, the mother was disease-free and the infant showed normal development and growth. Discussion: Sequential chemotherapy including epirubicin and paclitaxel should be taken into consideration as adjuvant treatment for pregnant women with high-risk breast cancer. The strong placental expression of P-glycoprotein may play a major role in limiting fetal exposure to anthracyclines and taxanes.

Original languageEnglish
Pages (from-to)5225-5229
Number of pages5
JournalAnticancer Research
Volume23
Issue number6 D
Publication statusPublished - Nov 2003

Keywords

  • Breast cancer
  • Chemotherapy
  • Epirubicin
  • P-glycoprotein
  • Paclitaxel
  • Pregnancy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Gadducci, A., Cosio, S., Fanucchi, A., Nardini, V., Roncella, M., Conte, P. F., & Genazzani, A. R. (2003). Chemotherapy with Epirubicin and Paclitaxel for Breast Cancer during Pregnancy: Case Report and Review of the Literature. Anticancer Research, 23(6 D), 5225-5229.