Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention

Francesco Vairo, Najmul Haider, Richard Kock, Francine Ntoumi, Giuseppe Ippolito, Alimuddin Zumla

Research output: Contribution to journalReview article

Abstract

Chikungunya, a zoonotic disease caused by the Chikungunya virus (CHIKV), is transmitted by infected Aedes spp mosquitoes. CHIKV has now spread to more than 100 countries and is listed on the WHO Blueprint priority pathogens. After an incubation period of 1 to 12 days, symptoms similar to other febrile infections appear, with a sudden onset of high fever, nausea, polyarthralgia, myalgia, widespread skin rash, and conjunctivitis. Serious complications include myocarditis, uveitis, retinitis, hepatitis, acute renal disease, severe bullous lesions, meningoencephalitis, Guillain-Barré syndrome, myelitis, and cranial nerve palsies. Treatment is supportive; there is no specific antiviral treatment and no effective vaccine.

Original languageEnglish
Pages (from-to)1003-1025
Number of pages23
JournalInfectious Disease Clinics of North America
Volume33
Issue number4
DOIs
Publication statusPublished - Dec 1 2019

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Keywords

  • Aedes spp
  • Arbovirus
  • Chikungunya
  • Diagnosis, prevention, and treatment
  • Epidemic
  • Mosquito
  • Zoonoses

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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