Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-α, but similar replication kinetics in non human primate cells

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Abstract

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalNew Microbiologica
Volume34
Issue number1
Publication statusPublished - Jan 2011

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Chikungunya virus
Interferons
Primates
Mutation
Alphavirus
Virus Replication
Culicidae
Antiviral Agents
Disease Outbreaks
Infection

Keywords

  • A226V mutation
  • Chikungunya
  • Interferon α
  • Pathogenesis

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

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title = "Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-α, but similar replication kinetics in non human primate cells",
abstract = "Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.",
keywords = "A226V mutation, Chikungunya, Interferon α, Pathogenesis",
author = "Licia Bordi and Silvia Meschi and Marina Selleri and Eleonora Lalle and Concetta Castilletti and Fabrizio Carletti and Roberta Chiappini and {Di Caro}, Antonino and {Rosaria Capobianchi}, Maria",
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T1 - Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-α, but similar replication kinetics in non human primate cells

AU - Bordi, Licia

AU - Meschi, Silvia

AU - Selleri, Marina

AU - Lalle, Eleonora

AU - Castilletti, Concetta

AU - Carletti, Fabrizio

AU - Chiappini, Roberta

AU - Di Caro, Antonino

AU - Rosaria Capobianchi, Maria

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AB - Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.

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KW - Interferon α

KW - Pathogenesis

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