Abstract
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.
Original language | English |
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Pages (from-to) | 87-91 |
Number of pages | 5 |
Journal | New Microbiologica |
Volume | 34 |
Issue number | 1 |
Publication status | Published - Jan 2011 |
Keywords
- A226V mutation
- Chikungunya
- Interferon α
- Pathogenesis
ASJC Scopus subject areas
- Microbiology (medical)