Abstract
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.
| Original language | English |
|---|---|
| Pages (from-to) | 87-91 |
| Number of pages | 5 |
| Journal | New Microbiologica |
| Volume | 34 |
| Issue number | 1 |
| Publication status | Published - Jan 2011 |
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Keywords
- A226V mutation
- Chikungunya
- Interferon α
- Pathogenesis
ASJC Scopus subject areas
- Microbiology (medical)
Cite this
Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-α, but similar replication kinetics in non human primate cells. / Bordi, Licia; Meschi, Silvia; Selleri, Marina; Lalle, Eleonora; Castilletti, Concetta; Carletti, Fabrizio; Chiappini, Roberta; Di Caro, Antonino; Rosaria Capobianchi, Maria.
In: New Microbiologica, Vol. 34, No. 1, 01.2011, p. 87-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-α, but similar replication kinetics in non human primate cells
AU - Bordi, Licia
AU - Meschi, Silvia
AU - Selleri, Marina
AU - Lalle, Eleonora
AU - Castilletti, Concetta
AU - Carletti, Fabrizio
AU - Chiappini, Roberta
AU - Di Caro, Antonino
AU - Rosaria Capobianchi, Maria
PY - 2011/1
Y1 - 2011/1
N2 - Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.
AB - Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for the first autochthonous Italian outbreak in 2007. A226V mutation in El has been associated with enhanced replication in A. albopictus vector. Possible involvement of this mutation in enhanced infection capability in primate cells and sensitivity to exogenous interferon (IFN)-α was investigated. No significant differences were observed between the two isolates in terms of replication kinetic, virus yield and cy-topathic effect (CPE). Interestingly, the A226V-carrying strain was more susceptible to the antiviral action of recombinant IFN-α. The interplay between A226V mutation and innate defence mechanisms needs further investigation.
KW - A226V mutation
KW - Chikungunya
KW - Interferon α
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=79952479523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952479523&partnerID=8YFLogxK
M3 - Article
C2 - 21344151
AN - SCOPUS:79952479523
VL - 34
SP - 87
EP - 91
JO - New Microbiologica
JF - New Microbiologica
SN - 1121-7138
IS - 1
ER -