Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma

Kate M. Scott, Michael Von Korff, Jordi Alonso, Matthias C. Angermeyer, Corina Benjet, Ronny Bruffaerts, Giovanni De Girolamo, Josep Maria Haro, Ronald C. Kessler, Viviane Kovess, Yutaka Ono, Johan Ormel, Jose Posada-Villa

Research output: Contribution to journalArticlepeer-review


Objectives: To investigate a) whether childhood adversity predicts adult-onset asthma; b) whether early-onset depressive/anxiety disorders predict adult-onset asthma; and c) whether childhood adversity and early-onset depressive/anxiety disorders predict adult-onset asthma independently of each other. Previous research has suggested, but not established, that childhood adversity may predict adult-onset asthma and, moreover, that the association between mental disorders and asthma may be a function of shared risk factors, such as childhood adversity. Methods: Ten cross-sectional population surveys of household-residing adults (=18 years, n = 18,303) assessed mental disorders with the Composite International Diagnostic Interview (CIDI 3.0) as part of the World Mental Health surveys. Assessment of a range of childhood family adversities was included. Asthma was ascertained by self-report of lifetime diagnosis and age of diagnosis. Survival analyses calculated hazard ratios (HRs) for risk of adult-onset (>age 20 years) asthma as a function of number and type of childhood adversities and early-onset (

Original languageEnglish
Pages (from-to)1035-1043
Number of pages9
JournalPsychosomatic Medicine
Issue number9
Publication statusPublished - Nov 2008


  • Anxiety disorders
  • Asthma
  • Childhood adversity
  • Comorbidity
  • Depressive disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology


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