Childhood cancer survival in Europe

G. Gatta, I. Corazziari, C. Magnani, R. Peris-Bonet, P. Roazzi, C. Stiller, W. Oberaigner, M. Jechova, M. Rousarova, H. H. Storm, T. Aareleid, T. Hakulinen, G. Hédelin, I. Tron, E. Le Gall, G. Launoy, I. Macé-Lesech, I. Faivre, G. Chaplain, P. M. CarliB. Lacour, N. Raverdy, C. Berger, F. Freycon, P. Grosclaude, I. Estève, P. Kaatsch, L. Tryggvadottir, F. Berrino, C. Allemani, P. Baili, L. Ciccolallo, G. Gatta, A. Micheli, M. Sant, E. Taussig, R. Capocaccia, E. Carrani, R. De Angelis, S. Hartley, P. Roazzi, M. Santaquilani, A. Tavilla, F. Valente, A. Verdecchia, S. Ferretti, P. Crosignani, G. Tagliabue, E. Conti, M. Vercelli, F. Pannelli, P. Mosciatti, M. Federico, M. E. Artioli, V. De Lisi, L. Serventi, C. Magnani, G. Pastore, L. Gafà, R. Tumino, F. Falcini, M. Budroni, E. Paci, E. Crocetti, P. Zambon, S. Guzzinati, M. Dalmas, F. Langmark, A. Andersen, J. Rachtan, M. Bielska-Lasota, Z. Wronkowski, M. Zwierko, I. Pleško, A. Obsitníková, V. Pompe-Kirn, I. Izarzugaza, C. Martinez-Garcia, I. Garau, C. Navarro, M. D. Chirlaque, E. Ardanaz, C. Moreno, J. Galceran, A. Torrella, L. Barlow, T. Möller, J. M. Lutz, M. Usel, J. W W Coebergh, A. Van Der Does-Van Den Berg, O. Visser, M. P. Coleman, C. Stiller, R. Black, D. Brewster

Research output: Contribution to journalArticlepeer-review


Background: EUROCARE-3 collected data from 45 population-based cancer registries in 20 countries on 24 620 European children aged from 0 to 14 years diagnosed with malignancy in the period 1990-1994. Methods: Five-year survival between countries was compared for all malignancies and for the major diagnostic categories, adjusting for age, and estimated average European survival weighting for differences in childhood populations. Results: For all cancers combined, survival variation was large (45% in Estonia to 90% in Iceland), and was generally low (60-70%) in eastern Europe and high (≥75%) in Switzerland, Germany and the Nordic countries (except Denmark). The Nordic countries had the highest survival for four of the seven major tumour types: nephroblastoma (92%), acute lymphoid leukaemia (85%), CNS tumours (73%) and acute non-lymphocytic leukaemia (62%). The eastern countries had lowest survival: 89% for Hodgkin's disease, 71% for nephroblastoma, 68% for acute lymphoid leukaemia, 61% for non-Hodgkin's lymphoma, 57% for central nervous system (CNS) tumours and 29% for acute non-lymphocytic leukaemia. Conclusions: The Nordic countries represent a survival gold standard to which other countries can aspire. Since most childhood cancers respond well to treatment, survival differences are attributable to differences in access (including referral and timely diagnosis) and use of modern treatments; however, the obstacles to access and application of standard treatments probably vary markedly with country.

Original languageEnglish
JournalAnnals of Oncology
Issue numberSUPPL.5
Publication statusPublished - 2003


  • Childhood tumours
  • Europe
  • Population-based study
  • Survival variation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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