Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study

E. Stagnaro, S. Parodi, A. Seniori Costantini, P. Crosignani, L. Miligi, O. Nanni, S. Piro, V. Ramazzotti, S. Rodella, R. Tumino, C. Vindigni, P. Vineis

Research output: Contribution to journalArticle

Abstract

Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55–1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41–1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.

Original languageEnglish
Pages (from-to)1572-1574
Number of pages3
JournalEpidemiology and Infection
Volume146
Issue number12
DOIs
Publication statusPublished - 2018

Fingerprint

Multiple Myeloma
Communicable Diseases
Case-Control Studies
Mumps
Chickenpox
Rubella
Whooping Cough
Measles
Hematologic Neoplasms
Infection
Logistic Models
Population

Keywords

  • case-control study
  • chickenpox
  • childhood infections
  • measles
  • multiple myeloma
  • mumps
  • pertussis
  • rubella

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Childhood infectious diseases and risk of multiple myeloma : an analysis of the Italian multicentre case-control study. / Stagnaro, E.; Parodi, S.; Costantini, A. Seniori; Crosignani, P.; Miligi, L.; Nanni, O.; Piro, S.; Ramazzotti, V.; Rodella, S.; Tumino, R.; Vindigni, C.; Vineis, P.

In: Epidemiology and Infection, Vol. 146, No. 12, 2018, p. 1572-1574.

Research output: Contribution to journalArticle

Stagnaro, E, Parodi, S, Costantini, AS, Crosignani, P, Miligi, L, Nanni, O, Piro, S, Ramazzotti, V, Rodella, S, Tumino, R, Vindigni, C & Vineis, P 2018, 'Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study', Epidemiology and Infection, vol. 146, no. 12, pp. 1572-1574. https://doi.org/10.1017/S0950268818001413
Stagnaro, E. ; Parodi, S. ; Costantini, A. Seniori ; Crosignani, P. ; Miligi, L. ; Nanni, O. ; Piro, S. ; Ramazzotti, V. ; Rodella, S. ; Tumino, R. ; Vindigni, C. ; Vineis, P. / Childhood infectious diseases and risk of multiple myeloma : an analysis of the Italian multicentre case-control study. In: Epidemiology and Infection. 2018 ; Vol. 146, No. 12. pp. 1572-1574.
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