TY - JOUR
T1 - Childhood infectious diseases and risk of multiple myeloma
T2 - an analysis of the Italian multicentre case-control study
AU - Stagnaro, E
AU - Parodi, S
AU - Costantini, A Seniori
AU - Crosignani, P
AU - Miligi, L
AU - Nanni, O
AU - Piro, S
AU - Ramazzotti, V
AU - Rodella, S
AU - Tumino, R
AU - Vindigni, C
AU - Vineis, P
PY - 2018/9
Y1 - 2018/9
N2 - Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.
AB - Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.
U2 - 10.1017/S0950268818001413
DO - 10.1017/S0950268818001413
M3 - Article
C2 - 29843844
VL - 146
SP - 1572
EP - 1574
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 12
ER -