Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study

E Stagnaro; S Parodi; A Seniori Costantini; P Crosignani; L Miligi; O Nanni; S Piro; V Ramazzotti; S Rodella; R Tumino; C Vindigni; P Vineis

doi:10.1017/S0950268818001413

Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study

E Stagnaro, S Parodi, A Seniori Costantini, P Crosignani, L Miligi, O Nanni, S Piro, V Ramazzotti, S Rodella, R Tumino, C Vindigni, P Vineis

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.

Original language	English
Pages (from-to)	1572-1574
Number of pages	3
Journal	Epidemiology and Infection
Volume	146
Issue number	12
DOIs	https://doi.org/10.1017/S0950268818001413
Publication status	Published - Sep 2018

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Stagnaro, E., Parodi, S., Costantini, A. S., Crosignani, P., Miligi, L., Nanni, O., Piro, S., Ramazzotti, V., Rodella, S., Tumino, R., Vindigni, C., & Vineis, P. (2018). Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study. Epidemiology and Infection, 146(12), 1572-1574. https://doi.org/10.1017/S0950268818001413

Childhood infectious diseases and risk of multiple myeloma : an analysis of the Italian multicentre case-control study. / Stagnaro, E; Parodi, S; Costantini, A Seniori; Crosignani, P; Miligi, L; Nanni, O; Piro, S; Ramazzotti, V; Rodella, S; Tumino, R; Vindigni, C; Vineis, P.

In: Epidemiology and Infection, Vol. 146, No. 12, 09.2018, p. 1572-1574.

Research output: Contribution to journal › Article › peer-review

Stagnaro, E, Parodi, S, Costantini, AS, Crosignani, P, Miligi, L, Nanni, O, Piro, S, Ramazzotti, V, Rodella, S, Tumino, R, Vindigni, C & Vineis, P 2018, 'Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study', Epidemiology and Infection, vol. 146, no. 12, pp. 1572-1574. https://doi.org/10.1017/S0950268818001413

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title = "Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study",

abstract = "Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.",

author = "E Stagnaro and S Parodi and Costantini, {A Seniori} and P Crosignani and L Miligi and O Nanni and S Piro and V Ramazzotti and S Rodella and R Tumino and C Vindigni and P Vineis",

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AU - Stagnaro, E

AU - Parodi, S

AU - Costantini, A Seniori

AU - Crosignani, P

AU - Miligi, L

AU - Nanni, O

AU - Piro, S

AU - Ramazzotti, V

AU - Rodella, S

AU - Tumino, R

AU - Vindigni, C

AU - Vineis, P

PY - 2018/9

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N2 - Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.

AB - Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.

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JO - Journal of Hygiene

JF - Journal of Hygiene

SN - 0950-2688

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ER -

Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study

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