TY - JOUR
T1 - Childhood narcolepsy with cataplexy
T2 - Comparison between post-H1N1 vaccination and sporadic cases
AU - Pizza, Fabio
AU - Peltola, Hanna
AU - Sarkanen, Tomi
AU - Moghadam, Keivan K.
AU - Plazzi, Giuseppe
AU - Partinen, Markku
PY - 2014/2
Y1 - 2014/2
N2 - Objectives: We aimed to compare post-Pandemrix® vaccination (postvaccine) childhood narcolepsy with cataplexy (NC) vs sporadic pre-H1N1 pandemic (pre-H1N1) cases. Methods: Clinical, anthropometric, polysomnographic, and cerebrospinal hypocretin 1 (hcrt-1) measurements were collected together with the video recordings of cataplexy in 27 Finnish patients with NC onset after H1N1 Pandemrix® vaccination (mean age, 12 ± 4. years; 52% boys) and 42 Italian NC patients with NC onset before the H1N1 pandemic (mean age, 11 ± 3. years; 48% boys). All subjects carried the HLA-DQB1*0602 allele. Results: Postvaccine subjects were older at NC onset (12 ± 3 vs 9 ± 3. years; P= .008) and displayed a shorter mean sleep latency in multiple sleep latency tests (MSLT) (2.3 ± 2.2 vs 3.7 ± 2.9 min; P= .026) compared to pre-H1N1 cases. Anthropometric, clinical (core NC symptoms), hcrt-1 deficiency, and polysomnographic data did not differ among groups, but higher disrupted nocturnal sleep was observed in postvaccine subjects. Comparison of cataplexy features at video assessment showed an overlapping picture with the exception for hyperkinetic movements which appeared to be more evident in pre-H1N1 subjects. Conclusions: The clinical picture of childhood NC was similar in postvaccine and pre-H1N1 children.
AB - Objectives: We aimed to compare post-Pandemrix® vaccination (postvaccine) childhood narcolepsy with cataplexy (NC) vs sporadic pre-H1N1 pandemic (pre-H1N1) cases. Methods: Clinical, anthropometric, polysomnographic, and cerebrospinal hypocretin 1 (hcrt-1) measurements were collected together with the video recordings of cataplexy in 27 Finnish patients with NC onset after H1N1 Pandemrix® vaccination (mean age, 12 ± 4. years; 52% boys) and 42 Italian NC patients with NC onset before the H1N1 pandemic (mean age, 11 ± 3. years; 48% boys). All subjects carried the HLA-DQB1*0602 allele. Results: Postvaccine subjects were older at NC onset (12 ± 3 vs 9 ± 3. years; P= .008) and displayed a shorter mean sleep latency in multiple sleep latency tests (MSLT) (2.3 ± 2.2 vs 3.7 ± 2.9 min; P= .026) compared to pre-H1N1 cases. Anthropometric, clinical (core NC symptoms), hcrt-1 deficiency, and polysomnographic data did not differ among groups, but higher disrupted nocturnal sleep was observed in postvaccine subjects. Comparison of cataplexy features at video assessment showed an overlapping picture with the exception for hyperkinetic movements which appeared to be more evident in pre-H1N1 subjects. Conclusions: The clinical picture of childhood NC was similar in postvaccine and pre-H1N1 children.
KW - Children
KW - Influenza
KW - Narcolepsy with cataplexy
KW - Pandemic H1N1
KW - Vaccination
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U2 - 10.1016/j.sleep.2013.09.021
DO - 10.1016/j.sleep.2013.09.021
M3 - Article
C2 - 24468101
AN - SCOPUS:84895116734
VL - 15
SP - 262
EP - 265
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 2
ER -