Childhood-onset HAM/TSP with progressive cognitive impairment

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection in childhood.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalNeurological Sciences
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2010

Fingerprint

HTLV-I Infections
Tropical Spastic Paraparesis
Paraparesis
Human T-lymphotropic virus 1
Spinal Cord Diseases
Sequence Analysis
Western Blotting
Genotype
Mothers
DNA
Cognitive Dysfunction

Keywords

  • Childhood
  • Cognitive impairment
  • HAM/TSP
  • HTLV-I

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Childhood-onset HAM/TSP with progressive cognitive impairment. / Zorzi, Giovanna; Mancuso, Roberta; Nardocci, Nardo; Farina, Laura; Guerini, Franca Rosa; Ferrante, Pasquale.

In: Neurological Sciences, Vol. 31, No. 2, 04.2010, p. 209-212.

Research output: Contribution to journalArticle

@article{ec9182507fd3439a88c25572507cc4d7,
title = "Childhood-onset HAM/TSP with progressive cognitive impairment",
abstract = "HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection in childhood.",
keywords = "Childhood, Cognitive impairment, HAM/TSP, HTLV-I",
author = "Giovanna Zorzi and Roberta Mancuso and Nardo Nardocci and Laura Farina and Guerini, {Franca Rosa} and Pasquale Ferrante",
year = "2010",
month = "4",
doi = "10.1007/s10072-009-0204-x",
language = "English",
volume = "31",
pages = "209--212",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "2",

}

TY - JOUR

T1 - Childhood-onset HAM/TSP with progressive cognitive impairment

AU - Zorzi, Giovanna

AU - Mancuso, Roberta

AU - Nardocci, Nardo

AU - Farina, Laura

AU - Guerini, Franca Rosa

AU - Ferrante, Pasquale

PY - 2010/4

Y1 - 2010/4

N2 - HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection in childhood.

AB - HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection in childhood.

KW - Childhood

KW - Cognitive impairment

KW - HAM/TSP

KW - HTLV-I

UR - http://www.scopus.com/inward/record.url?scp=77953539180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953539180&partnerID=8YFLogxK

U2 - 10.1007/s10072-009-0204-x

DO - 10.1007/s10072-009-0204-x

M3 - Article

C2 - 20076981

AN - SCOPUS:77953539180

VL - 31

SP - 209

EP - 212

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 2

ER -