Childhood refractory focal epilepsy following acute febrile encephalopathy

N. Specchio, L. Fusco, D. Claps, M. Trivisano, D. Longo, M. R. Cilio, M. Valeriani, R. Cusmai, S. Cappelletti, S. Gentile, G. Fariello, L. M. Specchio, F. Vigevano

Research output: Contribution to journalArticle

Abstract

Background: We describe a group of previously normal children who developed severe focal epilepsy after an acute/sub-acute illness resembling encephalitis. Methods: This is a retrospective study. An acute phase (encephalitis/encephalopathy period) and a chronic phase (chronic focal resistant epilepsy) were defined. Results: Eight patients were enrolled. The median age at onset was 6.6 years (range 8months-17.6years). In the acute phase, fever was the first symptom in all cases and was associated with seizures and status epilepticus. All patients had focal seizures arising in both hemispheres. Seizure onset occurred in the frontal and temporal regions. EEGs showed slowing background activity associated with focal or diffuse slow waves with rare epileptiform abnormalities. Cerebrospinal fluid oligoclonal bands were observed in four out of six patients tested. MRI images showed bilateral peri-insular hyperintensity in four cases. Five patients received corticosteroids, and in four cases, they were given along with intravenous immunoglobulins. The median duration of the acute phase was 19days (range 15-30days). During the chronic phase, which followed the acute phase without interval, patients presented with drug-resistant focal seizures and neuropsychological deficits, which ranged from hyperactivity and attention deficits to short-term verbal memory deficit, pervasive developmental disorders, and language delay. Conclusion: Considering the clinical presentations, EEG findings, and the associated occurrence of non-specific immunological activations, a possible immune-mediated pathogenesis can be hypothesized, although firm conclusions cannot be drawn out.

Original languageEnglish
Pages (from-to)952-961
Number of pages10
JournalEuropean Journal of Neurology
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Partial Epilepsy
Seizures
Encephalitis
Electroencephalography
Oligoclonal Bands
Language Development Disorders
Status Epilepticus
Intravenous Immunoglobulins
Memory Disorders
Brain Diseases
Temporal Lobe
Short-Term Memory
Age of Onset
Cerebrospinal Fluid
Adrenal Cortex Hormones
Fever
Retrospective Studies
Acute Febrile Encephalopathy
Pharmaceutical Preparations

Keywords

  • Encephalitis
  • Fever
  • Immune-mediated
  • Intravenous immunoglobulins
  • Refractory focal epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Childhood refractory focal epilepsy following acute febrile encephalopathy. / Specchio, N.; Fusco, L.; Claps, D.; Trivisano, M.; Longo, D.; Cilio, M. R.; Valeriani, M.; Cusmai, R.; Cappelletti, S.; Gentile, S.; Fariello, G.; Specchio, L. M.; Vigevano, F.

In: European Journal of Neurology, Vol. 18, No. 7, 07.2011, p. 952-961.

Research output: Contribution to journalArticle

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AU - Cusmai, R.

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