Childhood systemic lupus erythematosus: A review of 30 cases

A. Buoncompagni, G. C. Barbano, V. Pistoia, L. Fasce, C. Micalizzi, R. Gusmano, G. Cordone, F. Cottafava, P. G. Mori, E. Franchini, M. Ferrarini, C. Borrone

Research output: Contribution to journalArticlepeer-review


We review 30 cases of pediatric systemic lupus erythematosus followed over an 8-year period at our institution. The female to male ratio was 3.3:1; the age at diagnosis ranged between 3.5 and 16 years. On first admission, renal involvement was detected in the majority of the patients, as assessed by laboratory findings and/or clinical manifestations. Other frequently observed symptoms were fever, skin rashes, arthralgias and/or arthritis and serositis. All of the patients were treated with corticosteroids and most of them also received immunosuppressive drugs in order to control disease activity. Two patients were lost to the follow-up, five died and only one of the 23 evaluable patients is off therapy after a median follow-up of 5 years. This study confirms that pediatric systemic lupus erythematosus is a very aggressive disease.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalClinical and Experimental Rheumatology
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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