Children with recurrent otitis show defective IFNγ-producing cells in adenoids

Antonietta M. Avanzini, Anna Maria Castellazzi, Massimo Marconi, Chiara Valsecchi, Alessia Marseglia, Giorgio Ciprandi, Annalisa De Silvestri, Gian Luigi Marseglia

Research output: Contribution to journalArticlepeer-review


Infectious diseases are frequently observed in children and their recurrence represents a demanding challenge for the paediatrician. It has been hypothesized that a defective immune response may occur in these patients. The aim of the present study was to evaluate whether children presenting with recurrent otitis have a defective interferon (IFN)γ production by the lymphocytes of peripheral blood and of adenoid tissue, in comparison with children without recurrent otitis. Our study group was represented by 58 children undergoing adenoidectomy for adenoidal hypertrophy. They were subdivided into two groups according to the recurrence of otitis (≥3 per year) or not (

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalPediatric Allergy and Immunology
Issue number6
Publication statusPublished - Sep 2008


  • Adenoids
  • Children
  • Interferon-gamma
  • Lymphocytes
  • Recurrent otitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology


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