Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis

Maria Francesca Patria, Benedetta Longhi, Mara Lelii, Claudia Tagliabue, Marinella Lavelli, Carlotta Galeone, Nicola Principi, Susanna Esposito

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.

Original languageEnglish
Article number13
JournalItalian Journal of Pediatrics
Volume42
Issue number1
DOIs
Publication statusPublished - Feb 9 2016

Fingerprint

Bronchiectasis
Pneumonia
Fibrosis
Bronchodilator Agents
Spirometry
Respiratory Function Tests
Respiratory Sounds
Nose
Cystic Fibrosis
Outpatients
Thorax
Tomography
Demography
Pediatrics
Lung

Keywords

  • Bronchiectasis
  • Lower respiratory tract infections
  • Non-cystic fibrosis bronchiectasis
  • Pediatric pulmonology
  • Pneumonia
  • Recurrent pneumonia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis. / Patria, Maria Francesca; Longhi, Benedetta; Lelii, Mara; Tagliabue, Claudia; Lavelli, Marinella; Galeone, Carlotta; Principi, Nicola; Esposito, Susanna.

In: Italian Journal of Pediatrics, Vol. 42, No. 1, 13, 09.02.2016.

Research output: Contribution to journalArticle

Patria, Maria Francesca ; Longhi, Benedetta ; Lelii, Mara ; Tagliabue, Claudia ; Lavelli, Marinella ; Galeone, Carlotta ; Principi, Nicola ; Esposito, Susanna. / Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis. In: Italian Journal of Pediatrics. 2016 ; Vol. 42, No. 1.
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abstract = "Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 {\%} and 71.4 {\%} of those with, and 85.7 {\%} and 71.4 {\%} of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 {\%}) and two without (9.5 {\%}; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.",
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AU - Patria, Maria Francesca

AU - Longhi, Benedetta

AU - Lelii, Mara

AU - Tagliabue, Claudia

AU - Lavelli, Marinella

AU - Galeone, Carlotta

AU - Principi, Nicola

AU - Esposito, Susanna

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AB - Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.

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KW - Lower respiratory tract infections

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KW - Pediatric pulmonology

KW - Pneumonia

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