Abstract
Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.
| Original language | English |
|---|---|
| Article number | 13 |
| Journal | Italian Journal of Pediatrics |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 9 2016 |
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Keywords
- Bronchiectasis
- Lower respiratory tract infections
- Non-cystic fibrosis bronchiectasis
- Pediatric pulmonology
- Pneumonia
- Recurrent pneumonia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis. / Patria, Maria Francesca; Longhi, Benedetta; Lelii, Mara; Tagliabue, Claudia; Lavelli, Marinella; Galeone, Carlotta; Principi, Nicola; Esposito, Susanna.
In: Italian Journal of Pediatrics, Vol. 42, No. 1, 13, 09.02.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis
AU - Patria, Maria Francesca
AU - Longhi, Benedetta
AU - Lelii, Mara
AU - Tagliabue, Claudia
AU - Lavelli, Marinella
AU - Galeone, Carlotta
AU - Principi, Nicola
AU - Esposito, Susanna
PY - 2016/2/9
Y1 - 2016/2/9
N2 - Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.
AB - Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.
KW - Bronchiectasis
KW - Lower respiratory tract infections
KW - Non-cystic fibrosis bronchiectasis
KW - Pediatric pulmonology
KW - Pneumonia
KW - Recurrent pneumonia
UR - http://www.scopus.com/inward/record.url?scp=84957564879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957564879&partnerID=8YFLogxK
U2 - 10.1186/s13052-016-0225-z
DO - 10.1186/s13052-016-0225-z
M3 - Article
AN - SCOPUS:84957564879
VL - 42
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
SN - 1720-8424
IS - 1
M1 - 13
ER -