Chitosan micro- and nanospheres

Fabrication and applications for drug and DNA delivery

Andrea Masotti, Giancarlo Ortaggi

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Polysaccharides and other cationic polymers have been recently used in pharmaceutical research and industry for their properties to control the release of antibiotics, DNA, proteins, peptide drugs or vaccines. They have been also extensively studied as non viral DNA carriers for gene delivery and therapy. Chitosan is one of the most used since it can promote long-term release of incorporated drugs. Here, we reviewed the recent literature on the preparation of chitosan micro- and nanospheres using different manufacturing processes (nanofabrication). Moreover, the preparation of chitosan and chitosan/DNA nanospheres using a novel and simple osmosis-based method has been recently reported. This novel nanofabrication method may be a useful alternative to obtain small DNA-containing nanospheres (38 ± 4 nm) for biomedical applications. The reported method has general applicability to various synthetic or natural biopolymers. Solvent, temperature and membrane cut-off are the physicochemical parameters able to control the overall osmotic process leading to obtain several nanostructured systems with different size and shape that may be used in several biotechnological applications.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalMini-Reviews in Medicinal Chemistry
Volume9
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint

Nanospheres
Chitosan
Microspheres
DNA
Pharmaceutical Preparations
Osmosis
Biopolymers
Viral DNA
Drug Industry
Genetic Therapy
Polysaccharides
Polymers
Vaccines
Anti-Bacterial Agents
Peptides
Temperature
Membranes
Proteins

Keywords

  • Cationic polymers
  • Chitosan
  • DNA
  • Gene delivery
  • Microspheres
  • Nanospheres

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Chitosan micro- and nanospheres : Fabrication and applications for drug and DNA delivery. / Masotti, Andrea; Ortaggi, Giancarlo.

In: Mini-Reviews in Medicinal Chemistry, Vol. 9, No. 4, 2009, p. 463-469.

Research output: Contribution to journalArticle

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