CHK2 kinase in the DNA damage response and beyond

Laura Zannini, Domenico Delia, Giacomo Buscemi

Research output: Contribution to journalArticlepeer-review


The serine/threonine kinase CHK2 is a key component of the DNA damage response. In human cells, following genotoxic stress, CHK2 is activated and phosphorylates >20 proteins to induce the appropriate cellular response, which, depending on the extent of damage, the cell type, and other factors, could be cell cycle checkpoint activation, induction of apoptosis or senescence, DNA repair, or tolerance of the damage. Recently, CHK2 has also been found to have cellular functions independent of the presence of nuclear DNA lesions. In particular, CHK2 participates in several molecular processes involved in DNA structure modification and cell cycle progression. In this review, we discuss the activity of CHK2 in response to DNA damage and in the maintenance of the biological functions in unstressed cells. These activities are also considered in relation to a possible role of CHK2 in tumorigenesis and, as a consequence, as a target of cancer therapy.

Original languageEnglish
Pages (from-to)442-457
Number of pages16
JournalJournal of Molecular Cell Biology
Issue number6
Publication statusPublished - Dec 1 2014


  • apoptosis
  • checkpoints
  • DNA damage
  • genomic stability

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Genetics


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