Chlamydia pneumoniae

Francesco Blasi, Roberto Cosentini, Paolo Tarsia, Luigi Allegra

Research output: Contribution to journalArticlepeer-review


Recent data confirm the role of Chlamydia pneumoniae infection in a wide range of infections involving the upper and lower respiratory tract. Furthermore, it has now been shown that this previously considered relatively benign infection may be associated with severe forms of both pneumonia and chronic obstructive pulmonary disease exacerbations. An association between C. pneumoniae and asthma has more convincingly been established, and the line of research has now shifted to addressing whether chronic infection may actually affect the natural history of bronchial asthma. C. pneumoniae infection in immunocompromised patients is a relatively new and unexplored field that may open interesting future research. Given the increasing importance of this microorganism in respiratory medicine, the precise definition of optimal diagnostic techniques becomes mandatory. Specifically, the relative role of serology, culture, and nucleic acid amplification tests must still be determined. Although convincing in vitro data have been gathered on antibiotic activity toward C. pneumoniae, optimal dosing and length of treatment in vivo have not yet been defined. Should the role of C. pneumoniae infection be confirmed in chronic respiratory and extrapulmonary diseases, eradication of this microorganism and/or prevention of infection by means of large scale vaccination may prove to have a major impact on public health world wide.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalClinical Pulmonary Medicine
Issue number1
Publication statusPublished - 2002


  • Antibiotic treatment
  • Chlamydia pneumoniae
  • Diagnostic methods
  • Respiratory infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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