Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI study

Pierluigi Blanc, Anna Maria Corsi, Andrea Gabbuti, Cecilia Peduzzi, Francesca Meacci, Fabiola Olivieri, Fulvio Lauretani, Mazzotta Francesco, Luigi Ferrucci

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVES: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. DESIGN: Cross-sectional survey. SETTING: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). PARTICIPANTS: A total of 1,304 (age-range: 20-103, 79% aged ≥65) participants of the InCHIANTI study. MEASUREMENTS: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G ≥1/16 and <1/256, and recent CPI was defined as IgG ≥ 1/512 or IgM ≥ 1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-α), IL-1β, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. RESULTS: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P <.01). CPI was not associated with IL-1β, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-á (P <.01), IL-6 (P <.03), sIL-6R (P <.01), and hypertension (P <.02). In additional age and sex-adjusted models, the associations between CPI and TNF-α, IL-6, sIL-6r, and hypertension appeared to be mutually independent. CONCLUSION: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-α, IL-6, and sIL-6r.

Original languageEnglish
Pages (from-to)1626-1631
Number of pages6
JournalJournal of the American Geriatrics Society
Volume52
Issue number10
DOIs
Publication statusPublished - Oct 2004

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Chlamydophila pneumoniae
Interleukin-6 Receptors
Interleukin-6
Tumor Necrosis Factor-alpha
Hypertension
Infection
Ferritins
Interleukin-1
C-Reactive Protein
Body Mass Index
Iron
Immunoglobulin G
Smoking
Lipids
Chlamydia Infections
Interleukin-1 Receptors
Interleukins
Italy
Fluorescent Antibody Technique
Immunoglobulin M

Keywords

  • Chlamydia pneumoniae
  • Cytokines
  • Elderly
  • Inflammation

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Chlamydia pneumoniae seropositivity and cardiovascular risk factors : The InCHIANTI study. / Blanc, Pierluigi; Corsi, Anna Maria; Gabbuti, Andrea; Peduzzi, Cecilia; Meacci, Francesca; Olivieri, Fabiola; Lauretani, Fulvio; Francesco, Mazzotta; Ferrucci, Luigi.

In: Journal of the American Geriatrics Society, Vol. 52, No. 10, 10.2004, p. 1626-1631.

Research output: Contribution to journalArticle

Blanc, P, Corsi, AM, Gabbuti, A, Peduzzi, C, Meacci, F, Olivieri, F, Lauretani, F, Francesco, M & Ferrucci, L 2004, 'Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI study', Journal of the American Geriatrics Society, vol. 52, no. 10, pp. 1626-1631. https://doi.org/10.1111/j.1532-5415.2004.52453.x
Blanc, Pierluigi ; Corsi, Anna Maria ; Gabbuti, Andrea ; Peduzzi, Cecilia ; Meacci, Francesca ; Olivieri, Fabiola ; Lauretani, Fulvio ; Francesco, Mazzotta ; Ferrucci, Luigi. / Chlamydia pneumoniae seropositivity and cardiovascular risk factors : The InCHIANTI study. In: Journal of the American Geriatrics Society. 2004 ; Vol. 52, No. 10. pp. 1626-1631.
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abstract = "OBJECTIVES: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. DESIGN: Cross-sectional survey. SETTING: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). PARTICIPANTS: A total of 1,304 (age-range: 20-103, 79{\%} aged ≥65) participants of the InCHIANTI study. MEASUREMENTS: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G ≥1/16 and <1/256, and recent CPI was defined as IgG ≥ 1/512 or IgM ≥ 1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-α), IL-1β, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. RESULTS: The prevalence of CP seropositivity was 75{\%}, increased with age, and was higher in men than in women (P <.01). CPI was not associated with IL-1β, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-{\'a} (P <.01), IL-6 (P <.03), sIL-6R (P <.01), and hypertension (P <.02). In additional age and sex-adjusted models, the associations between CPI and TNF-α, IL-6, sIL-6r, and hypertension appeared to be mutually independent. CONCLUSION: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-α, IL-6, and sIL-6r.",
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T2 - The InCHIANTI study

AU - Blanc, Pierluigi

AU - Corsi, Anna Maria

AU - Gabbuti, Andrea

AU - Peduzzi, Cecilia

AU - Meacci, Francesca

AU - Olivieri, Fabiola

AU - Lauretani, Fulvio

AU - Francesco, Mazzotta

AU - Ferrucci, Luigi

PY - 2004/10

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N2 - OBJECTIVES: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. DESIGN: Cross-sectional survey. SETTING: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). PARTICIPANTS: A total of 1,304 (age-range: 20-103, 79% aged ≥65) participants of the InCHIANTI study. MEASUREMENTS: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G ≥1/16 and <1/256, and recent CPI was defined as IgG ≥ 1/512 or IgM ≥ 1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-α), IL-1β, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. RESULTS: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P <.01). CPI was not associated with IL-1β, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-á (P <.01), IL-6 (P <.03), sIL-6R (P <.01), and hypertension (P <.02). In additional age and sex-adjusted models, the associations between CPI and TNF-α, IL-6, sIL-6r, and hypertension appeared to be mutually independent. CONCLUSION: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-α, IL-6, and sIL-6r.

AB - OBJECTIVES: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. DESIGN: Cross-sectional survey. SETTING: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). PARTICIPANTS: A total of 1,304 (age-range: 20-103, 79% aged ≥65) participants of the InCHIANTI study. MEASUREMENTS: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G ≥1/16 and <1/256, and recent CPI was defined as IgG ≥ 1/512 or IgM ≥ 1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-α), IL-1β, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. RESULTS: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P <.01). CPI was not associated with IL-1β, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-á (P <.01), IL-6 (P <.03), sIL-6R (P <.01), and hypertension (P <.02). In additional age and sex-adjusted models, the associations between CPI and TNF-α, IL-6, sIL-6r, and hypertension appeared to be mutually independent. CONCLUSION: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-α, IL-6, and sIL-6r.

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