Chlamydia trachomatis and invasive cervical cancer: A pooled analysis of the IARC multicentric case-control study

Jennifer S. Smith, Cristina Bosetti, Nubia Muñoz, Rolando Herrero, F. Xavier Bosch, José Eluf-Neto, Chris J L M Meijer, Adriaan J C Van Den Brule, Silvia Franceschi, Rosanna W. Peeling

Research output: Contribution to journalArticle

Abstract

To determine whether Chlamydia trachomatis infection is consistently associated with an increased risk of invasive cervical carcinoma (ICC) after accounting for the strong effect of human papillomavirus (HPV) infection, a case-control study of 1,238 cases of ICC and 1,100 control women from 7 countries was carried out (hospital-based studies in Thailand, the Philippines, Morocco, Peru, Brazil and population-based studies in Colombia and Spain, all coordinated by the International Agency for Research on Cancer, Lyon, France). C. trachomatis serum antibody detection was made by means of a microfluorescence assay. Among HPV DNA-positive cases and controls, the risk of squamous cell ICC was elevated in C. trachomatis seropositive women (OR = 1.8; 95% CI = 1.2-2.7) after adjustment for age, center, oral contraceptive use, history of Pap smears, number of full-term pregnancies and herpes simplex virus 2 seropositivity. The effect of C. trachomatis seropositivity on squamous cell ICC risk increased with increasing C. trachomatis antibody titers and was higher in women under 55 years of age. C. trachomatis antibodies were not associated with adeno- or adenosquamous cell carcinoma (OR = 1.0; 95% CI = 0.53-1.9) in HPV DNA-positive women. An association of C. trachomatis with squamous cell ICC was found among all cases and control women with or without adjustment for HPV.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalInternational Journal of Cancer
Volume111
Issue number3
DOIs
Publication statusPublished - Sep 1 2004

Keywords

  • Cervical cancer
  • Chlamydia trachomatis
  • Human papillomavirus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Smith, J. S., Bosetti, C., Muñoz, N., Herrero, R., Bosch, F. X., Eluf-Neto, J., Meijer, C. J. L. M., Van Den Brule, A. J. C., Franceschi, S., & Peeling, R. W. (2004). Chlamydia trachomatis and invasive cervical cancer: A pooled analysis of the IARC multicentric case-control study. International Journal of Cancer, 111(3), 431-439. https://doi.org/10.1002/ijc.20257