Chlamydial infection

The link with ocular adnexal lymphomas

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Chlamydiae are obligate intracellular bacteria that grow in eukaryotic cells and cause a wide spectrum of diseases. They can establish persistent infections, are mitogenic in vitro, promote polyclonal cell proliferation in vivo and induce resistance to apoptosis in infected cells-properties that might contribute to tumorigenesis. In fact, Chlamydophila psittaci (Cp) has been linked to the development and maintenance of ocular adnexal marginal zone B-cell lymphoma (OAMZL). In this indolent malignancy, Cp is transported by monocytes and macrophages and causes both local and systemic infection. Cp elementary bodies are viable and infectious in the conjunctiva and peripheral blood of patients with OAMZL. Bacterial eradication with antibiotic therapy is often followed by lymphoma regression. Despite recent advances in the understanding of this bacterium-lymphoma association, several questions remain unanswered. For instance, prevalence variations among different geographical areas and related diagnostic and therapeutic implications remain a major investigational issue. We will focus on clinical and therapeutic implications of chlamydial infections in patients with lymphomas and summarize the current knowledge on the association between Cp infection and OAMZL. Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed.

Original languageEnglish
Pages (from-to)658-669
Number of pages12
JournalNature Reviews Clinical Oncology
Volume6
Issue number11
DOIs
Publication statusPublished - 2009

Fingerprint

Chlamydophila psittaci
Marginal Zone B-Cell Lymphoma
Lymphoma
Infection
Chlamydophila Infections
Bacteria
Chlamydia
Conjunctiva
Eukaryotic Cells
Monocytes
Carcinogenesis
Epidemiology
Therapeutics
Macrophages
Maintenance
Cell Proliferation
Apoptosis
Anti-Bacterial Agents
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Chlamydial infection : The link with ocular adnexal lymphomas. / Ferreri, A. J M; Dolcetti, Riccardo; Magnino, Simone; Doglioni, Claudio; Ponzoni, Maurilio.

In: Nature Reviews Clinical Oncology, Vol. 6, No. 11, 2009, p. 658-669.

Research output: Contribution to journalArticle

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