Abstract
Chlamydophila pneumoniae DNA and mRNA transcripts were investigated by PCR and RT-PCR in fresh CSF and PBMC specimens co-cultured in Hep-2 cell lines and collected from 14 patients with definite RR MS and 19 patients with other inflammatory (OIND) and non-inflammatory (NIND) neurological controls. A positivity for C. pneumoniae DNA and mRNA was detected in CSF and PBMCs of 9 RR MS patients (64.2%) with evidence of disease activity, whereas only 3 controls were positive for Chlamydial DNA. These preliminary findings suggest that C. pneumoniae may occur in a persistent and metabolically active state at both peripheral and intrathecal levels in MS, but not in OIND and NIND.
Original language | English |
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Pages (from-to) | 58-61 |
Number of pages | 4 |
Journal | Neuroscience Research |
Volume | 62 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sep 2008 |
Keywords
- Cerebrospinal fluid
- Chlamydophila pneumoniae
- Culture
- Multiple sclerosis
- PBMC
- PCR
- RT-PCR
ASJC Scopus subject areas
- Neuroscience(all)