Chlamydophila pneumoniae infection and its role in neurological disorders

Carlo Contini, Silva Seraceni, Rosario Cultrera, Massimiliano Castellazzi, Enrico Granieri, Enrico Fainardi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of C. pneumoniae in a large number of persons suffering from different diseases including cardiovascular (atherosclerosis and stroke) and central nervous system (CNS) disorders. Despite this, many important issues remain unanswered with regard to the role that C. pneumoniae may play in initiating atheroma or in the progression of the disease. A growing body of evidence concerns the involvement of this pathogen in chronic neurological disorders and particularly in Alzheimer's disease (AD) and Multiple Sclerosis (MS). Monocytes may traffic C. pneumoniae across the blood-brain-barrier, shed the organism in the CNS and induce neuroinflammation. The demonstration of C. pneumoniae by histopathological, molecular and culture techniques in the late-onset AD dementia has suggested a relationship between CNS infection with C. pneumoniae and the AD neuropathogenesis. In particular subsets of MS patients, C. pneumoniae could induce a chronic persistent brain infection acting as a cofactor in the development of the disease. The role of Chlamydia in the pathogenesis of mental or neurobehavioral disorders including schizophrenia and autism is uncertain and fragmentary and will require further confirmation.

Original languageEnglish
Article number273573
JournalInterdisciplinary Perspectives on Infectious Diseases
Volume2010
DOIs
Publication statusPublished - 2010

Fingerprint

Chlamydophila pneumoniae
Nervous System Diseases
Alzheimer Disease
Infection
Multiple Sclerosis
Central Nervous System Infections
Culture Techniques
Chlamydia
Central Nervous System Diseases
Atherosclerotic Plaques
Autistic Disorder
Blood-Brain Barrier
Disease Progression
Monocytes
Schizophrenia
Atherosclerosis
Central Nervous System
Myocardial Infarction
Brain

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Parasitology
  • Virology

Cite this

Contini, C., Seraceni, S., Cultrera, R., Castellazzi, M., Granieri, E., & Fainardi, E. (2010). Chlamydophila pneumoniae infection and its role in neurological disorders. Interdisciplinary Perspectives on Infectious Diseases, 2010, [273573]. https://doi.org/10.1155/2010/273573

Chlamydophila pneumoniae infection and its role in neurological disorders. / Contini, Carlo; Seraceni, Silva; Cultrera, Rosario; Castellazzi, Massimiliano; Granieri, Enrico; Fainardi, Enrico.

In: Interdisciplinary Perspectives on Infectious Diseases, Vol. 2010, 273573, 2010.

Research output: Contribution to journalArticle

Contini, C, Seraceni, S, Cultrera, R, Castellazzi, M, Granieri, E & Fainardi, E 2010, 'Chlamydophila pneumoniae infection and its role in neurological disorders', Interdisciplinary Perspectives on Infectious Diseases, vol. 2010, 273573. https://doi.org/10.1155/2010/273573
Contini, Carlo ; Seraceni, Silva ; Cultrera, Rosario ; Castellazzi, Massimiliano ; Granieri, Enrico ; Fainardi, Enrico. / Chlamydophila pneumoniae infection and its role in neurological disorders. In: Interdisciplinary Perspectives on Infectious Diseases. 2010 ; Vol. 2010.
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