TY - JOUR
T1 - Chloride intracellular channel protein 1 (CLIC1) Δs over-expressed in muscle invasive urinary bladder cancer
AU - Adelmann, Tiberiu Gabriel
AU - Camerota, Tommaso Ciro
AU - Ceausu, Amalia Raluca
AU - Cimpean, Anca Maria
AU - Mazzanti, Michele
AU - Raica, Marius
N1 - Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Background/Aim: Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in relation to different stages of bladder cancer development. Materials and Methods: Immunohistochemistry for CLIC1 was applied in 50 cases of muscle invasive bladder cancer. Results: CLIC1 was not expressed in the normal urothelium, but a strong reaction was observed in dysplastic urothelium, carcinoma in situ and in 94% of the cases with invasive urothelial carcinoma; however, it was not expressed in squamous cell carcinoma cases. No correlation was found between the immunohistochemical expression of CLIC1 and the stage and grade of the tumour. Conclusion: CLIC1 was overexpressed in urinary bladder dysplastic epithelium, carcinoma in situ and invasive carcinoma. CLIC1 constitutes a new potential marker of invasive bladder cancer.
AB - Background/Aim: Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in relation to different stages of bladder cancer development. Materials and Methods: Immunohistochemistry for CLIC1 was applied in 50 cases of muscle invasive bladder cancer. Results: CLIC1 was not expressed in the normal urothelium, but a strong reaction was observed in dysplastic urothelium, carcinoma in situ and in 94% of the cases with invasive urothelial carcinoma; however, it was not expressed in squamous cell carcinoma cases. No correlation was found between the immunohistochemical expression of CLIC1 and the stage and grade of the tumour. Conclusion: CLIC1 was overexpressed in urinary bladder dysplastic epithelium, carcinoma in situ and invasive carcinoma. CLIC1 constitutes a new potential marker of invasive bladder cancer.
KW - Bladder cancer
KW - Chloride intracellular channel protein 1 (CLIC1)
KW - Immunohistochemistry
KW - Potential therapeutic target
KW - Prognosis
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U2 - 10.21873/anticanres.14710
DO - 10.21873/anticanres.14710
M3 - Article
C2 - 33288580
AN - SCOPUS:85097483632
VL - 40
SP - 6879
EP - 6884
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 12
ER -