Chlorpromazine and glucose metabolism

A. Jori, D. Bernardi, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Chlorpromazine in low doses (1.25 mg kg) reduces the tolerance to glucose load for more than 24 hr. The effect is not related to changes in body temperature and is present in both adrenalectomized and adrenal demedullated rats. Part of this effect of chlorpromazine is related to changes in permeability as shown by the decreased disappearance from blood stream of arabinose, a sugar which is not phosphorilated, after arabinose load.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalNeuropharmacology
Volume3
Issue number6
Publication statusPublished - Dec 1964

ASJC Scopus subject areas

  • Medicine(all)
  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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