Cholecalciferol supplementation in HIV-infected youth with vitamin d insufficiency: Effects on vitamin d status and t-cell phenotype: A randomized controlled trial

Vania Giacomet, Alessandra Vigano, Valeria Manfredini, Chiara Cerini, Giorgio Bedogni, Stefano Mora, Manuela Borelli, Daria Trabattoni, Gian Zuccotti

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: In addition to its known effects on bone metabolism, vitamin D may regulate immune function. Design: We performed a randomized controlled trial (RCT) to test whether cholecalciferol supplementation can improve vitamin D status and affect the T-cell phenotype in HIV-infected youth with vitamin D insufficiency. Methods: Fifty-two HIV-infected patients aged 8 to 26 years and with serum 25(OH) D 2D, PTH, and CD4+ T cells were assessed 3 months before baseline and at 0, 3, 6, 9, and 12 months, while Th1-, Th2-, Th17-, and Treg-subsets and T-lymphocyte vitamin D receptor were assessed at 0, 3, and 12 months. Results: Forty-eight subjects (25 receiving vitamin D and 23 receiving placebo) completed the RCT. Cholecalciferol supplementation produced an early (3 months) decrease in PTH, a concomitant increase in 25(OH)D, and a later (6 months) increase in 1,25(OH)2D levels, all persisting at 12 months. The frequency of vitamin D insufficiency at 12 months was 20% versus 60% in the intervention versus placebo group (P =.007). Cholecalciferol supplementation had no effect on CD4+ T-cell counts but was associated with a decreased Th17:Treg ratio at 3 months. Conclusions: In our cohort of HIV-infected youth, a 12-month cholecalciferol supplementation increased 25(OH)D and 1-25(OH)2D and decreased PTH levels but had no effect on CD4+ T-cells. However, it was associated with changes in CD4+ T-cell phenotype, warranting further investigation.

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalHIV Clinical Trials
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1 2013

Keywords

  • adolescents
  • children
  • HIV
  • immunity
  • vitamin D

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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