Cholecystokinin, β-endorphin and vasoactive intestinal peptide in peripheral blood mononuclear cells of drug-naive schizophrenic patients treated with haloperidol compared to healthy controls

Massimo C. Mauri, Renata Rudelli, Stefano Vanni, Gabriele Panza, Aldo Sicaro, Daniele Audisio, Paola Sacerdote, Alberto E. Panerai

Research output: Contribution to journalArticlepeer-review

Abstract

Cholecystokinin (CCK), β-endorphin (BE), and vasoactive intestinal peptide (VIP) in peripheral blood mononuclear cells from 30 drug-naive schizophrenics compared to 22 healthy controls were studied. Patients were evaluated with the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of the Negative Symptoms (SANS) at baseline (TO), and after four weeks (T4) in nine patients who were subsequently treated with haloperidol (HL). Neuropeptide concentrations in peripheral blood mononuclear cells (PBMC) were measured at T0 and, for the treated patients, at T4. There was a negative correlation between CCK and SANS baseline scores and a trend for patients who responded poorly to HL (i.e. patients with a prevalence of negative symptomatology) to have lower CCK basal values.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalPsychiatry Research
Volume78
Issue number1-2
DOIs
Publication statusPublished - Mar 20 1998

Keywords

  • β-Endorphin
  • Cholecystokinin
  • Haloperidol
  • Schizophrenia
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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